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    History of the department

        The Department of General Practitioner's Training in Therapy No. 2 was established at the Samarkand State Medical Institute in 1999. The department was headed by the Doctor of Medical Sciences, Professor Nazira Musaevna Khaitova for 12 years. From 2013 to the present day, the department is headed by The Doctor of Medical Sciences, Associate Professor Eleonora Negmatovna Tashkenbaeva. In addition to internal diseases, family medicine for the graduation courses of the faculties of emergency, treatment, medical and pedagogical faculties in the department, after switching to a credit-module education system in 2013 (the name of the department has been changed to Internal Diseases No.2), the basis of internal diseases; therapy and clinical allergology for students of 3-4 courses of the faculty of dentistry; For 2 courses of the Faculty of Higher Nursing Preparedness, a course was taught in an internal disease clinic, such as nursing. Since 2016, 3-4 undergraduate students in internal medicine have begun studying on the basis of the department. These are urgent cases at the Internal Medicine Clinic; they were embarrassed by practical training from such subjects as family medicine. Since the first days of the establishment of the clinical base, classes have been conducted at the Samarkand branch of the Regional Emergency Medical Center, including the 2nd Emergency Therapy Department, and the 2,3,4,7,8,12 family clinics in Samarkand. The department RSHTTYOIM Samarkand branch is located on the basis of emergency therapy education.

         Scientific   and  methodological activity of the Department of Internal Medicine and Cardiology no. 2  is directly related to  the  scientific department of  the Samarkand branch of  RSHTTIIM. Since 2002, E. N. Tashkenanova, assistant professor of therapy at the 2nd UASH, headed the scientific department of the therapeutic department. The research activity is aimed at further improving the work of therapeutic service in Samarkand branch and improving their professional quality, searching for optimal methods of treating patients in urgent situations, ensuring continuity of hospitalized and hospitalized stages of emergency medical care. The structural reorganization of the branch office ensured the largest integration of research work between the staff of the department and the department, which led to a significant increase in outgoing publications. Today, the 2nd Department of Internal Diseases and Cardiology, together with SFRMT staff, is actively participating in international and national scientific conferences, seminars, symposiums, and syezds. During the 20th year of the work of the Department of Internal Diseases No. 2 of SamSMI, a number of research works are underway to improve the treatment of automatic patients in situations that cannot be delayed to this day. Organizational forms, composition and content of the department were changed, improved and combined with the Samarkand branch at various stages of its development. The staff of the department is actively involved in medical and scientific research in the field of emergency medicine. Thanks to the direct participation of scientists of the Institute, the main stages of hospital assistance have been established in the Samarkand region, complex and intensive care methods have been introduced, and the real possibilities of effective treatment in life-threatening conditions have been expanded. The faculty and associate professors of the department provide constant differential diagnostic assistance to patients with an inconclusive diagnosis.

        Under the leadership of Khaitova N.M., more than 100 scientific articles have been published. Heitova spoke and spoke at several scientific conferences abroad and in the republic with scientific lectures from N.M.uz. Heitova N.M. Worked in a number of positions, such as vice-president of the U.S. Association for Reproductive Health, a member of the editor-in-chief of the Journal of Uzbek Medicine, and a depputati in Samarkand. Under the direction of Hayitova N.M., 4 nominations and 2 doctoral dissertations were performed. During the course of the department 8 clinical ordinators and 7 masters in the specialty of internal diseases were trained.

        Together with the staff of the department conducted research on the use of laser therapy for chronic bronchitis, bronchitis, myocardial infarction, hypertension; studying the immunological reactivity of the body in order to expand ideas about the etiology and pathogenesis of respiratory diseases and to develop tests that are useful in clinical practice.

        From 2009 to 2011, D.Sc. was one of the scientific directions of the department "Development of new technologies for the diagnosis, differentiated therapy, prevention and immunoreabitation of patients with bronchopulmonal" system pathology under the guidance of Professor N. M. Khaitova. The staff of the department actively participate in the life of the Center and regular scientific, clinical conferences and master classes on the current problems of modern medicine are held in order to improve the qualifications of RSHTTYOIMSF doctors. Since 2013, he has been head of the Department of Emergency Therapy No. 2, Under the guidance of D.Sc.Eleanora Negmatovna Tashkenanova, under her leadership 25 masters in the specialty of "cardiology" of The SamSMU, 24 clinical ordinators and 20 clinical ordinators of RNTSEMP SF in the specialty of "internal diseases", 2 PhDs in medical science were defended.

        From 2011 to 2014, research was carried out on "Developing methods of correcting symptom-free hyperuricemia to prevent the development of cardiovascular complications", A10-SS-0154, adSS5, PPI-10 "Improving public health protection by developing new technologies and diagnostics, treatment, disease prevention methods." According to the results of the study, 52 scientific papers, monographs on "symptom-free hyperuricemia: pathogenetic aspects, clinics, forecasting and correction", "Science" edition of the Academy of Sciences of the Republic of Uzbekistan, Tashkent -2014; Textbook on "Clinical Pharmacology of Drugs Used in Cardiovascular Diseases"; IAP was patented for the invention of "endothelial dysfunction correction method" no. 05346.

        Since 2015, the scientific and technical problem addressing the activities of the Department of Internal Diseases No. 2 has increased interest in finding hereditary factors that are prone to the development of cardiovascular disease today. One of the main scientific areas is the study of the allegiance polymorphism association of candidate genes with the risk of developing heart ischemic disease (YUIK). Despite much work on this subject done in leading genetic laboratories around the world, the data on the effects of certain genes on the development of corollary artery disease is often vague. This is due to ethnic differences; pleiotropic effects of genes; the presence of subclinical phenotypes; factors that do not take into account the phenotypical representation of an individual's genetic characteristics, etc. To this end, the role of biochemical markers, which reflects endothelial dysfunction and the development of oxidative stress, is studied in various clinical courses related to BSU, later developing methods of molecular-genetic forecasting of unstable variants of the angina pectory, and the effectiveness of the adapted approach.

        Since 2018, under the direction of E. N., the Department of SamMI and the Scientific Department of Emergency Therapy of RSHTTYOIMSF . Tashkenanova PPI - 149 "development of new types and methods of differential therapy and prevention of diseases, as well as research on the practical program "The negative impact of environmental factors on the basis of detection of genetic polymorphism and other determinants of pathological conditions of the human body", according to the PZ-20170927280 agreement, "develop molecular-genetic methods for predicting unstable variants of angina pectory and theiron the theme "A Tailored Approach to Therapy." The staff of the department is currently conducting research in the following areas:

    •  Introduction of IHD in samarkand on the basis of redistribution of gravitational forces in the solar system;
    •  Studying how to correct endothelial dysfunction in patients with corronary heart disease;
    •  Studying the frequency of acquaintance with dilation cardiomyopathy in emergency medical conditions;
    •  Studying the clinical appearance, diagnosis, treatment, and forecasting characteristics of early complications of miocardial infarction in an emergency hospital;
    •  Optimize antiarrhythmic treatment for patients with acute miocardial infarction;

        Studying optimal approaches to treating patients with acute coronuscular syndrome using modern methods of systemic thrombolysis, high-tech methods of diagnosis and treatment

        To date, more than 130 scientific publications have been published in these areas, including 4 scientific papers in the Scopus database, 1 textbook entitled "Coronary Heart Disease" - 1 monograph" Molecular-genetic aspects of CHD in the context of asymptomatic hyperuricemia in the country", 2 Software program:" An adapted approach to the treatment of unstable variants of angina pector", "Based on the redistribution of gravitational forces of the solar system to SamarkandIHD aggression forecast _Samarkand-I.exe)", "Method of selecting patients for the treatment of CHD depending on the genotypus" was filed with the invention patent.

        Also at the department were leading scientists such as T.F.n., docent Kuyliev Murodullo Umarovich, t.f.n., docent Maxmudov M.B., t.f.n., docent Kazimova L.F., Ashrapov X.A., Ishankulova D.K., Turdibekov X.I., Ziyadullaev Sh.X., among them.Sh. X. Ziyadhullayev (Vice-Rector for Scientific Research and Innovation of SamSU from 2020 to the present day). 3 monographs, more than 100 scientific and educational articles and essays published by the staff of the department in local and leading foreign journals. Teachers of the department constantly learn their knowledge and professional skills. They will pass through the United States, Eta, Russia and other MDH countries to improve their skills.

        By Kuyliev M.U. "Some thoughts about spirituality" and "Teacher and Disciple" books published. At that time, the staff of the department regularly improved their skills in foreign countries.

        Currently, there are 9 employees working in the department. There are  1 doctor of medical sciences and 8 assistant teachers.

        More than 130 scientific papers have been published in these areas so far, including 4 scientific papers in the Scopus database, 1 textbook entitled "Medium Ischemic Disease" - 1 monograph " Molecular-genetic aspects of CAD in the context of symptomless hyperuricemia in the country", 2 Sofware program: "A tailored approach to the treatment of unstable variants of the angina pector", "Based on the redistribution of gravitational forces of the solar system to Samarkand  A patent for the invention of _Samarkand-I.exe) to predict CAD anemia was filed.

        The staff of the department regularly attend international conferences with lectures and attendences. 

        Together with employees of the Department of Emergency Therapy   and employees of the 2nd Department of Internal Diseases, they  regularly hold  scientific practical conferences.     Also, in the districts and districts of Samarkand, emergency medical  services are scheduled to  go to more than 200  calls and conduct  a planned and urgent examination of patients .  In the departments   assigned to the center, patients are  consultative and actively participating in   pathological anatomical conferences.

        The department regularly brings master's degrees and clinical ordinations in cardiology and therapy. The current problems of science are constantly being thoroughly addressed by masters and clinical ordinators.