The Department of Pharmaceutical and Toxicological Chemistry of Samarkand State Medical University places particular emphasis on the development of scientific research, the implementation of research findings in the educational process, and their practical application in pharmaceutical and medical practice. The research activities of the academic staff are carried out within the approved scientific areas of the Department and cover such relevant fields as pharmaceutical, toxicological, organic and analytical chemistry, biochemistry, medicinal plant raw materials, medicinal chemistry, biologically active compounds, and the development of modern biomedical materials.

  At present, the academic staff of the Department are conducting research in the following major areas:

• Azim Kenjaevich Baykulov — application of chitosan derivatives in medicine, investigation of their biological activity, assessment of their therapeutic potential, and development of new medicinal and biomedical materials;
• Tohir O‘tirovich Anvarov — catalytic synthesis of C₂–C₁₂ aliphatic normal and isonitriles, investigation of organic synthesis mechanisms and the properties of the resulting compounds;
• Feruz Nizomiddinovich Toshboev — investigation of the kinetic regularities of the oxyacetylation of ethylene and study of the factors affecting the rate and efficiency of catalytic processes;
• Ziroat Erkinovna O‘runboeva — synthesis of a series of substituted 3,4-dihydro- and 1,2,3,4-tetrahydroisoquinolines and investigation of their chemical properties and potential biological activity;
• Mavjuda Ergashboevna Eshkobilova — development of chemical sensors for methane monitoring and investigation of modern gas-sensitive materials and sensor systems;
• Odilboy Safarovich Tashanov — development of the composition and technology of a gel containing comfrey root extract for use in the treatment of diseases and lesions of the oral mucosa;
• Javokhir Zoyirovich Ahmadov — chemical investigation of plants of the Lagochilus genus, study of biologically active compounds of plant origin, and assessment of their pharmacological potential.

  Scientific Achievements and Publication Activity

  During the 2022–2025 academic years, the academic staff of the Department published more than 200 scientific and educational-methodological works. According to the Department's official information, during this period 11 teaching manuals, 7 monographs, 222 scientific articles, and 100 conference abstracts were prepared. The scientific publications include papers published in national and international journals, including articles indexed in the international Scopus database.

  An important achievement of the Department's scientific activity was the successful defense of PhD dissertations by Tohir O‘tirovich Anvarov and Ziroat Erkinovna O‘runboeva. In addition, Associate Professor Mavjuda Ergashboevna Eshkobilova successfully defended her doctoral (DSc) dissertation, which represents a significant achievement and an important indicator of the scientific potential and development of the Department's scientific school.

  The Department's research activities are not limited to the publication of scientific articles. The academic staff regularly participate in scientific conferences, develop new research areas, prepare PhD and DSc dissertations, involve undergraduate and master's students in research projects, and introduce research findings into the educational process.

  Scientific Publications of the Department's Staff in 2025–2026

  During 2025–2026, the research activity of the Department's academic staff continued to expand. Scientific works were published in various areas of pharmaceutical chemistry, toxicology, biochemistry, organic synthesis, pharmaceutical analysis, and biomedical research.

1. Azim Kenjaevich Baykulov

• Oxidative Stress and Lipid Peroxidation in Experimental Myocardial Infarction: Biochemical Evaluation in Cardiac and Hepatic Tissue — a study investigating oxidative stress and lipid peroxidation processes in experimental myocardial infarction;
• Assessment of Coagulation Activity and Hemoben Application in Patients with Extensive Burns — a study assessing changes in the hemostatic system in patients with extensive burns and the application of the Hemoben hemostatic agent;
• Extraction of Alkaloids and Processes Occurring in the Body — a study devoted to the extraction of alkaloids and investigation of their processes in the body;
• Experimental Hyperhomocysteinemia under Conditions of Oxidative Stress — a study investigating experimental hyperhomocysteinemia under conditions of oxidative stress.

2. Feruz Nizomiddinovich Toshboev

• Experimental Myocardial Infarction LDH Bilan Correction of Natijalari — a study devoted to the correction of lactate dehydrogenase parameters in experimental myocardial infarction;
• Qon Tomir Kasalliklarida eNOSning O‘rni — a study investigating the role of endothelial nitric oxide synthase (eNOS) in vascular diseases;
• Of Organic Substances by Thin Layer Chromatographic Method — a study devoted to the analysis of organic substances using thin-layer chromatography.

3. Mavjuda Ergashboevna Eshkobilova

• Response Time and Recovery Time of a Semiconductor Sensor for Detecting Methane and Natural Gas — a study of the response and recovery times of semiconductor sensors for detecting methane and natural gas;
• Advancements in Surgical Techniques: A Comprehensive Review — a review article devoted to advances in modern surgical techniques;
• Gidrazidlarning biologik faolligi fosforlangan karboksilik kislotalar va ularning hosilalari — a study of the biological activity of hydrazides and phosphorylated carboxylic acid derivatives;
• Lipidlаr asosida sirt faol moddalarni olish — a study of the synthesis of surfactants based on lipids;
• Dori vositalari tahlilida konduktometriya usulini qo‘llash — a study devoted to the application of conductometric methods in pharmaceutical analysis;
• Gaz xromatografik usulda namunalarni tahlilga tayyorlash va dori moddalarni chinligini aniqlash — a study of sample preparation and identification of pharmaceutical substances using gas chromatography.

4. Odilboy Safarovich Tashanov

• Lipidlаr asosida sirt faol moddalarni olish — a study devoted to the preparation of surfactants based on lipids;
• Gidrazidlarning biologik faolligi fosforlangan karboksilik kislotalar va ularning hosilalari — a study investigating the biological activity of hydrazides and phosphorylated carboxylic acid derivatives.

5. Tohir O‘tirovich Anvarov

• Mineral Elements of Rubia tinctorum L. Roots and Their Application in Medicine — a study of the mineral composition of Rubia tinctorum L. roots and their potential applications in medicine;
• Glutamin Aminokislotasi: Biologik Ahamiyati, Fiziologik Funksiyalari va Tibbiyotda Qo‘llanilishi — a study devoted to the biological significance, physiological functions, and medical applications of the amino acid glutamine.

6. Javokhir Zoyirovich Ahmadov

• Odam organizmida askorbin kislotasi (C vitamini) yetishmovchiligi va uni baholash usullari — a study devoted to vitamin C deficiency in the human body and methods for its assessment;
• participated as a co-author in a scientific study devoted to the analysis of organic substances using thin-layer chromatography.

  Prospective Areas of Scientific Research

  In 2025–2026, the Department's scientific research activities continued to develop in several interconnected areas. Particular attention is being paid to the synthesis and investigation of new biologically active compounds, development of pharmaceutical formulations based on natural raw materials, investigation of chitosan derivatives, improvement of pharmaceutical and toxicological analytical methods, development of chemical sensors, study of the biochemical mechanisms of pathological processes, and identification of promising agents for their correction.

  Further development of international scientific cooperation, increasing the number of publications in international peer-reviewed journals indexed in major bibliographic databases, training highly qualified scientific personnel, expanding PhD and DSc research, and involving undergraduate and master's students more actively in scientific research remain among the Department's priority objectives.

  Overall, the scientific research activities of the Department of Pharmaceutical and Toxicological Chemistry are aimed at strengthening its scientific potential, training highly qualified researchers, obtaining new scientific results, and implementing these results in pharmaceutical and medical practice as well as in the educational process.