Gepato-gastroenterologik tadqiqotlar jurnali 2022, №4

Subject of the article

ME’DA ADENOKARSINOMALARIDA ERBB2 EKSPRESSIYASI VA UNING AHAMIYATINI O'RGANISH (51-53)

Authors

Mallayev M.M.; O’lmasov F. G’.

Institution

Samarqand davlat tibbiyot universiteti

Abstract

Saraton kasalligi insoniyatning hozirgacha yechimi topilmagan va bu borada uzluksiz ilmiy izlanishlar jadal davom etayotgan muammolaridan biridir. Kasallikning oxirgi yillar mobaynida ko‘payishi hamda olib borilayotgan muolajalarga qaramasdan, davo natijalarining sezilarli samara bermayotgan sohani molekulyar darajada o‘rganishga turtki bo‘lmoqda. Meʼda saratoni dunyoda uchrashi jihatidan onkologik kasalliklar ichida beshinchi va o‘lim ko‘rsatkichi bo‘yicha uchinchi o‘rinda turadi. O‘zbekistonda kasallanish bo‘yicha erkaklarda beshinchi, ayollarda yettinchi o‘rinni egallagan.

Key words

meʼda saratoni, adenokarsinoma, ERBB2, target davo.

Literature

1. Cunningham D, Starling N, Rao S, et al. Capecitabine and Oxaliplatin for Ad-vanced Esophagogastric Cancer. N. Engl. J. Med., Jan 2008; 358: 36 – 46 2. Dikshit R, Gupta PC, Ramasundarahettige C, Gajalakshmi V, Aleksandrowicz L, Badwe R, et al. Cancer mortality in India: a nationally representative survey. Lancet. 2012;379(9828):1807–16. 3. Koss L.G., Melamed M.R. Koss Diagnostic Cytology and Its Histopathologic Basis. Philadelphia: Lippincott Williams & Wilkins, 2006. 4. Lordick F, Allum W, Carneiro F, Mitry E, Tabernero J, Tan P. Unmet needs and challenges in gastric cancer: The way forward. Cancer Treat Rev. 2014;40(6):692–700. 5. Liu X, Chu KM. E-cadherin and gastric cancer : cause, consequence, and applications. Biomed Res Int. 2014;doi:10.1155/2014/637308. 6. Pouget J.P., Navarro-Teulon I., Bardiès M., et al. Clinical radioimmunotherapy - the role of radiobiology. Nat. Rev. Clin. Oncol. 2011. 8: P.720–734. 7. Tafe LJ, Janjigian YY, Zaidinski M, Hedvat CV, Hameed MR, Tang LH, et al. Human Epidermal Growth Factor Receptor 2 Testing in Gastroesophageal Cancer: Correlation Between Immunohistochemistry and Fluorescence In Situ Hybridization. Arch Pathol Lab Med. 2011;135(11):1460–5. 8. Tubbs R.R., Stoler M.H. Cell and Tissue Based Molecular Pathology E-Book. Philadelphia: Elsevier Health Sciences, 2009. P. 452 9. Younes A. Beyond chemotherapy: new agents for targeted treatment of gastric cancer. Nat Rev Clin Oncol 2011; 8: P.85–96. 10. Zeldis JB, Knight R, Hussein M, et al. A review of the history, properties, and use of the immunomodulatory compound lenalidomide. Ann N Y Acad Sci 2011; 1222:P.76–82.