Биология ва тиббиёт муаммолари 2026, №3 (169)
Subject of the article
PERSONALIZED APPROACHES TO RESTORING REPRODUCTIVE FUNCTION IN WOMEN AFTER SURGICAL TREATMENT OF OVARIAN ENDOMETRIOSIS (23-27)
Authors
Agababyan Larisa Rubenovna, Shonazarova Sitora Iskandarovna
Institution
Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Abstract
Purpose of the study. To evaluate the effectiveness of individualized approaches to restoring reproductive function after surgical treatment of ovarian endometriosis. Materials and methods. The study included 65 women aged 23 to 33 with ovarian endometriosis who underwent laparoscopic surgery. Before and 6 months after surgical interven-tion, ovarian reserve parameters were assessed, including the level of anti-Müllerian hormone (AMH) and the number of antral follicles (AFC). All patients underwent individually selected postoperative rehabilitation. The ob-servation period was 9 months. Results. 6 months after surgery, AMH levels decreased from 3.1 to 2.5 ng/ml, and the AFC indicator decreased from 11.8 to 10.1. Despite the decrease in ovarian reserve indicators, reproductive potential was maintained. During the observation period, pregnancy occurred in 5 patients, accounting for 7.7% of the total number of examined women. Conclusion. Individualized rehabilitation following surgical treatment of ovarian endometriosis contributes to the preservation of reproductive function and the improvement of fertility.
Key words
ovarian endometriosis, laparoscopy, reproductive function, fertility, AMH, AFC, rehabilitation.
Literature
1. Адамян Л.В., Андреева Е.Н., Арсланян К.Н. Современные аспекты диагностики и лечения эн-дометриоза // Акушерство и гинекология. 2022. №4. С. 5–12. 2. Ризаев Ж. А., Агабабян И. Р. Место статинов в лечении хронического пародонтита у больных атеросклерозом коронарных артерий //Экспериментальная и клиническая гастроэнтеро-логия. – 2026. – №. 12. – С. 62-67. 3. Ризаев Ж. А., Агабабян Л. Р. Давлатова Азиза, Ахмедова Азиза Тайировна, Расулова Феруза Го-либовна //Состояние полости рта у первоберемен-ных. – 2023. – Т. 4. – №. 4. 4. Ризаев Ж. А. и др. Острый миелоидный лейкоз в пакистанской больнице с ограниченными ресур-сами //Главный редактор. – 2024. – Т. 12. – №. 3. – С. 248. 5. Ризаев Ж. А. и др. Значение коморбидных со-стояний в развитии хронической сердечной недо-статочности у больных пожилого и старческого возраста //Достижения науки и образования. – 2022. – №. 1 (81). – С. 75-79. 6. Carbonell M., Dolz M., Casals G. Fertility preser-vation in endometriosis: review of current evidence // Gynecological Endocrinology. 2024. Vol. 40. No. 2. P. 101–108. 7. Chon S.J., Lee Y.J., Kim S.H. Oocyte cryopres-ervation for women with endometriosis // Clinical and Experimental Reproductive Medicine. 2024. Vol. 51. No. 4. P. 245–254. 8. Elizur S.E., Chiantera V., Soriano D. Fertility preservation for women with ovarian endometriosis // Reproductive BioMedicine Online. 2023. Vol. 46. No. 3. P. 521–529. 9. Grigoriadis G., Pantos K., Simopoulou M. Evi-dence on serum anti-Müllerian hormone levels and reproductive outcomes after endometrioma surgery // Journal of Clinical Medicine. 2025. Vol. 14. No. 11. Article 3772. 10. Kalaitzopoulos D.R., Nirgianakis K., Mueller M.D. Fertility preservation in women with endome-triosis // Journal of International Medical Research. 2026. Vol. 54. No. 2. 11. La Marca A., Sunkara S.K. Fertility preservation in women with endometriosis // Human Reproduc-tion Open. 2025. Vol. 2025. No. 2. Article hoaf012. 12. Li Y., Wang H., Zhang X. Impact of endometri-otic cystectomy on ovarian reserve and reproductive outcomes // Frontiers in Endocrinology. 2025. Vol. 16. Article 1687765. 13. Pecorella G., Candiani M., Vercellini P. Endome-triosis and reproductive-sparing surgery // Journal of Clinical Medicine. 2026. Vol. 15. No. 1. Article 380. 14. Younis J.S., Shapso N., Fleming R. The impact of ovarian endometrioma and endometriotic cystec-tomy on ovarian reserve: an appraisal of systematic reviews // Frontiers in Endocrinology. 2024. Vol. 15. Article 1397279. 15. Yu E.H., Chan C.H.Y., Ma H.K. Commentary on the new 2022 European Society of Human Repro-duction and Embryology guideline for endometriosis // Clinical and Experimental Reproductive Medicine. 2022. Vol. 49. No. 4. P. 233–235.