Биология ва тиббиёт муаммолари 2025 №6 (166)
Subject of the article
МЕСТНО-РАСПРОСТРАНЕННЫЙ И МЕТАСТАТИЧЕСКИЙ РАК ЖЕЛУДКА: ТЕНДЕНЦИИ ЛЕЧЕНИЯ (361-365)
Authors
Баймаков Сайфиддин Рисбаевич, Адилходжаев Аскар Анварович, Хуснуддинов Низомуддин Зухруддин угли, Рисбоев Рамзиддин Сайфиддинович
Institution
1 - Ташкентский государственный медицинский университет, Республика Узбекистан, г. Ташкент; 2 - Республиканский специализированный научно-практический медицинский центр онкологии и радиологии, Республика Узбекистан, г. Ташкент; 3. – Международный Университет «Кимё» в Ташкенте, Республика Узбекистан, г. Ташкент
Abstract
Ситуация, отражающая состояние диагностики и лечения рака желудка драматична: у 65% больных к моменту обращения диагностируются III и IV стадии заболевания, у 83% есть метастазы в регионарных лимфоузлах, а одногодичная летальность среди впервые обратившихся достигает 57%. Различные схемы мультимодальной терапии пока малоэф-фективны и хирургическое лечение остается единст-венным шансом больных на долгосрочную выживае-мость.
Key words
рак желудка, химиотерапия, радиотерапия, химиолучевая терапия.
Literature
1. Li, Q., et al., Magnetic anchoring and guidance-assisted endoscopic irreversible electroporation for gastric mucosal ablation: a preclinical study in canine model. Surg Endosc, 2021. 35(10): p. 5665-5674. 2. Takizawa, K., et al., A nonrandomized, single-arm confirmatory trial of expanded endoscopic submucosal dissection indication for undifferentiated early gastric cancer: Japan Clinical Oncology Group study (JCOG1009/1010). Gastric Cancer, 2021. 24(2): p. 479-491. 3. Duan, K., et al., Risk Factors and Timing of Additional Surgery after Noncurative ESD for Early Gastric Cancer. Can J Gastroenterol Hepatol, 2022. 2022: p. 3421078. 4. Boghossian, M.B., et al., EUS-guided gastroenterostomy versus duodenal stent placement and surgical gastrojejunostomy for the palliation of malignant gastric outlet obstruction: a systematic review and meta-analysis. Langenbecks Arch Surg, 2021. 406(6): p. 1803-1817. 5. Kim, G.H., et al., Recent Updates in Gastrointestinal Stent Placement from the Esophagus to the Colon: A Radiological Perspective. Cardiovasc Intervent Radiol, 2022. 45(4): p. 425-437. 6. Shike, M., et al., Direct percutaneous endoscopic jejunostomies for enteral feeding. Gastrointest Endosc, 1996. 44(5): p. 536-40. 7. Ilson, D.H., Advances in the treatment of gastric cancer: 2020-2021. Curr Opin Gastroenterol, 2021. 37(6): p. 615-618. 8. Hacker, U., A. Hoffmeister, and F. Lordick, [Gastric Cancer: diagnosis and current treatment strategies]. Dtsch Med Wochenschr, 2021. 146(23): p. 1533-1537. 9. Bacalbasa, N., et al., Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review). Exp Ther Med, 2021. 22(5): p. 1314. 10. Shen, J., et al., Adjuvant SOX chemotherapy versus concurrent chemoradiotherapy after D2 radical resection of locally advanced esophagogastric junction (EGJ) adenocarcinoma: study protocol for a randomized phase III trial (ARTEG). Trials, 2021. 22(1): p. 753. 11. Kim, D.W., et al., Neoadjuvant versus Postoperative Chemoradiotherapy is Associated with Improved Survival for Patients with Resectable Gastric and Gastroesophageal Cancer. Ann Surg Oncol, 2022. 29(1): p. 242-252. 12. Smalley, S.R., et al., Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. J Clin Oncol, 2012. 30(19): p. 2327-33. 13. Hazard, L., J. O'Connor, and C. Scaife, Role of radiation therapy in gastric adenocarcinoma. World J Gastroenterol, 2006. 12(10): p. 1511-20. 14. Moertel, C.G., et al., Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet, 1969. 2(7626): p. 865-7. 15. A comparison of combination chemotherapy and combined modality therapy for locally advanced gastric carcinoma. Gastrointestinal Tumor Study Group. Cancer, 1982. 49(9): p. 1771-7. 16. Hallissey, M.T., et al., The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. Lancet, 1994. 343(8909): p. 1309-12. 17. Zhang, Z.X., et al., Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (AGC)--report on 370 patients. Int J Radiat Oncol Biol Phys, 1998. 42(5): p. 929-34. 18. Тилляшайхов, М. Н., Адилходжаев, А. А., Худояров, С. С., Рахимов, О. А., Бойко, Е. В., Хасанов, Ш. Т., ... & Отабоев, А. Х. Первый опыт лапароскопической гастрэктомии с d2 лимфодиссекцией. Ўзбекистон хирургияси, 91. 19. Moningi, S., et al., IMRT Reduces Acute Toxicity in Patients Treated With Preoperative Chemoradiation for Gastric Cancer. Adv Radiat Oncol, 2020. 5(3): p. 369-376. 20. Trip, A.K., et al., IMRT limits nephrotoxicity after chemoradiotherapy for gastric cancer. Radiother Oncol, 2014. 112(2): p. 289-94. 21. Rizaev J. A. et al. Immunological and Clinical Aspects of Oral Inflammatory Diseases in the Development of Postpartum Septic Complications //International Journal of Integrative and Modern Medicine. – 2024. – Т. 2. – №. 12. – С. 253-257. 22. Rizaev J. A. et al. Physico-chemical parameters of mixed saliva and their correction in patients in the post-covid period //Cardiometry. – 2022. – №. 25. – С. 1168-1173. 23. Rizaev J. A., Khazratov A. I., Iordanishvili A. K. Morphofunctional characteristics of the mucous membrane of the masticatory apparatus in experimental carcinogenesis // Russian Journal of Dentistry. – 2021. – Т. 25. – №. 3. – С. 225-231. 24. Ng, S.P. and T. Leong, Role of Radiation Therapy in Gastric Cancer. Ann Surg Oncol, 2021. 28(8): p. 4151-4157. 25. Shinde, A., et al., The evolving role of radiation therapy for resectable and unresectable gastric cancer. Transl Gastroenterol Hepatol, 2019. 4: p. 64. 26. Macdonald, J.S., et al., Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med, 2001. 345(10): p. 725-30. 27. Hamasaki, T., et al., [Two Cases of Unresectable Gastric Cancer Where Bleeding Was Controlled by Radiation]. Gan To Kagaku Ryoho, 2020. 47(13): p. 2364-2366. 28. Hashimoto, K., et al., Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience. J Cancer Res Clin Oncol, 2009. 135(8): p. 1117-23. 29. Al-Batran, S.E. and S. Lorenzen, Management of Locally Advanced Gastroesophageal Cancer: Still a Multidisciplinary Global Challenge? Hematol Oncol Clin North Am, 2017. 31(3): p. 441-452. 30. Cai, Z., et al., Comparative effectiveness of preoperative, postoperative and perioperative treatments for resectable gastric cancer: A network meta-analysis of the literature from the past 20 years. Surg Oncol, 2018. 27(3): p. 563-574. 31. Coccolini, F., et al., Neoadjuvant chemotherapy in advanced gastric and esophago-gastric cancer. Meta-analysis of randomized trials. Int J Surg, 2018. 51: p. 120-127. 32. Al-Batran, S.E., et al., Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet, 2019. 393(10184): p. 1948-1957. 33. Ychou, M., et al., Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol, 2011. 29(13): p. 1715-21. 34. Cats, A., et al., Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial. Lancet Oncol, 2018. 19(5): p. 616-628. 35. Cunningham, D., et al., Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med, 2006. 355(1): p. 11-20. 36. Dikken, J.L., et al., Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer. J Clin Oncol, 2010. 28(14): p. 2430-6. 37. Ajani, J.A., et al., Phase II trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (RTOG 9904): quality of combined modality therapy and pathologic response. J Clin Oncol, 2006. 24(24): p. 3953-8. 38. van Hagen, P., et al., Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med, 2012. 366(22): p. 2074-84.