Биология ва тиббиёт муаммолари 2025 №6 (166)
Subject of the article
MONITORING OF NITROXIDERGIC SYSTEM INDICATORS IN THE TREATMENT OF ACUTE AND CHRONIC PURULENT RHINOSINUSITIS (252-256)
Authors
Faizullaev Dilshod Shodievich
Institution
Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Abstract
Acute and chronic purulent rhinosinusitis represent a significant medical and social problem, affecting 5-15% of the adult population and 5% of children. Despite advances in diagnosis and treatment, the role of the nitroxidergic system in the pathogenesis of these diseases remains poorly understood. The aim of this study was to evaluate the functional state of the nitroxidergic system to determine the course of rhinosinusitis and improve treatment effectiveness. This prospective, randomized study involved 120 patients with acute and chronic purulent rhinosinusitis and 25 healthy volunteers. Significant impairment of nitroxidergic system parameters was demonstrated in rhinosinusitis, and its correction improves treatment outcomes.
Key words
Acute rhinosinusitis, chronic rhinosinusitis, nitric oxide system, nitric oxide, mucociliary clearance, quality of life, complex treatment.
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