Биология ва тиббиёт муаммолари 2024 №1 (151)
Subject of the article
COMPARATIVE RELATIONSHIP OF MARKERS OF INFLAMMATORY CHANGES IN PERIPHERAL BLOOD IN PERSONS SUFFERING WITH CHRONIC PAIN SYNDROME IN DORSOPATHIES (263-270)
Authors
Khakimova Sоhiba Ziyadullayevna, Ahmedova Charos Zafarovna
Institution
Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Abstract
Dorsopathy, a frequently occurring condition characterized by aseptic inflammation in the spine, has not been thoroughly examined in terms of inflammatory markers. However, conducting a blood test to measure acute phase proteins and inflammatory markers can provide a comprehensive analysis of various proteins that tend to increase during inflammatory processes in the body. Therefore, it is essential to investigate the indicators and establish a comparative correlation between inflammatory markers in the peripheral blood of patients suffering from chronic pain syndrome in dorsopathy. A total of 320 individuals suffering from chronic pain syndrome with dorsopathies of different origins, who are currently undergoing treatment at the neurology department of the City Medical Association of Samarkand from 2018 to 2021, were carefully chosen for this study. In order to assess their condition, we employed blood tests to measure acute phase proteins and inflammatory markers such as fibrinogen, C-reactive protein, and interleukin-1β. The study findings from patients with different types of dorsopathies, such as compression-ischemic, brucellosis, rheumatic, and herpetic, indicate that fibrinogen, C-reactive protein, and interleukin-1β could serve as valuable biochemical indicators for distinguishing patients with chronic pain syndrome in dorsopathies of different origins. Various indicators of an inflammatory process, which provoke chronic pain, were observed in patients with chronic pain syndrome caused by compression-ischemic dorsopathies, brucellosis, rheumatic and herpetic origins. These indicators include the concentrations of fibrinogen, C-reactive protein, and interleukin-1β in the blood serum. These findings confirm the inflammatory nature of the pain and explain its chronic and persistent course.
Key words
inflammation markers, fibrinogen, C-reactive protein, interleukin-1β, dorsopathy.
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