Gepato-gastroenterologik tadqiqotlar jurnali 2021, № 4
Subject of the article
PECULIARITIES OF THE MANIFESTATION OF FOOD ALLERGIES ALLERGIES IN CHILDREN WITH ATOPIC DERMATITIS (100-103)
Authors
Ganiev A.G., Temirova O.H., Abdullayeva Sh.N.
Institution
Андижанский государственный медицинский институт
Abstract
The aim of the study was to determine the clinical and immunological individualities of food allergy (FA) in children with atopic dermatitis (AD). Eighty-eight children with AD between 2 and 14 years of age (16% were preschool children and 84% were children older than 8 years) suffering from a stubborn course of different acquired pathology were included in the examination. Immunological examination included determination of values of allergen-specific IgE and IgG antibodies in blood serum to food allergens (cow's milk protein, α-lactoalbumin, β-lactoglobulin, casein, soy protein, goat milk protein) conducted with support of special Allergopharma test systems. We monitored 95 children with AD (52 boys, 43 girls) aged from 1, 5 months to 3 years (mean age 14, 05 ± 1, 3 months). From 1, 5 to 12 months there were 55 (57, 9%) children, from 1 to 3 years respectively 40 (42, 1%) children. The disease manifested for the first time in 78 (82, 5%) children under 6 months of age, in 17 (17, 5%) children after 6 months. Of the total number of ill children, 48 (50, 9%) had an uneasy course (SCORAD index was 58, 14 ± 2, 63 points); 32 (33, 3%) children had a moderate course (SCORAD index - 32, 03 ± 1, 43 points), and 15 (15, 8%) children had an unsevere course (SCORAD index -12, 12 ± 1, 43 points). On the basis of the results obtained, it is possible to imagine that the immunopathogenesis of AD is characterized mostly by the impact of pro-inflammatory interleukins: IL-4, IL-5 and associated with increased vigor Th2-cells. Thus, allergological examination of young children with determination of IgE and Ig G to even more common PA allows us to detect the peculiarities of the immune response, which determine the features of the clinical manifestations of AD.
Key words
Keywords: atopic dermatitis, food allergy, features of manifestation, types of allergic reactions
Literature
1. Alexandieva Z.A. Risk factors for atopic dermatitis / Z.A. Aleksandiev // 2. Allergology and Immunology. 2012.-T.13.-№1.-p.14. 3. Vorontsov I.M., Matalygina O.A. Diseases associated with food sensitization in 4. children. - L .: Medicine, 2006. - 135-140 p. 5. Ganiev A.G., Abdurashidov A.A. Pathogenetic aspects of immunity in the development of food allergies / Republican scientific and practical videoconference with international participation // "Innovations in medicine and medical education" Andijan, December 7-8, 2018. Art.198-203. 6. Smirnova S.V. Allergy and pseudo-allergy (to the issues of prevalence, etiology, pathogenesis, differential diagnosis and therapy. - Krasnoyarsk: Grotesque, 1997- 220 p. 7. Cheburkin A.A. About multiorgan atopic diseases in children / Pogomiy NN, Chistyakov G. M. // Ros.vestn. perinatol. and pediatrician. - 2004. - V. 39. - № 3. - P. 22-25. 8. Kemmerer G. Allergic diathesis and allergic diseases: Trans. - M. - L .: State. Publishing house biol. and honey. lit., 2006. - 418 p. 9. 7.Babna S L Dilemma of pathogenesis and diagnosis of food allergy // Immunol. Allergy Clin. North. Am. - 2012. № 7, - P. 299-312. 10. Ganiev, A. G., Nazarov, D. K., Orumbaeva Z. O., Abdurashidov, A. A. Actual 11. problems of modern science // 4 times per year.2-3,2018 s. 12. D'Netto M. Allergic gastroenteropathy in preterm infants / M. D'Netto, V. Herson, N. Hussain et al. // J Pediatr. - 20. V. 137 (4). - № 10. - P. 480-486. 13. 10.Nogaller AM. Immunologic reactivity in patients with food allergy // Klin. Med. (Mosk). - 2011. - V. 69. - № 6, - P. 80-84.