Doktor axborotnomasi 2022, №3.1 (107)
Subject of the article
COVID-19 AND CLINIC LABORATORY DIAGNOSTICS (86-89)
Authors
D. A. Madaripova
Institution
Bukhara state medical institute, Bukhara, Uzbekistan
Abstract
The pandemic of a new coronavirus infection has caused an urgent need to develop, validate and put into practice effective methods of laboratory diagnostics that allow to verify the etiology of the disease, determine the presence of an immune response and its phase, as well as assess a wide range of pathophysiological disorders and complications arising from COVID-19. In the context of the COVID-19 pandemic, the important place of laboratory diagnostics is beyond doubt. It is the means and methods of laboratory diagnostics that are of fundamental importance for identifying those infected, including when the disease is asymptomatic or symptoms have not yet appeared, as well as for objectively determining the severity of the condition.
Key words
pandemic, COVID-19, PCR, SARS-CoV-2, laboratory diagnostics.
Literature
1. Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)», версия 7 от 03.06.2020). Доступно по адресу: https://static-0.rosminzdrav.ru/system/attachments/attaches/000/050/584/ original/03062020_МR_COVID-19_v7.pdf. Ссылка активна на 03 сентября 2020 г 2. Adhikari S.P., Meng S., Wu Y.J. et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. 2020;9(1):29. DOI: 10.1186/s40249-020-00646-x. 3. Anvarovich R. A., Anvarovna N. S. The influence of deficiency of microelements in children with bronchial hyperreactivity //Вестник науки и образования. – 2020. – №. 24-2 (102). 4. Anvarovna N. S. Features Of Kidney Damage at Patients with Ankylosing Spondiloarthritis //Texas Journal of Medical Science. – 2021. – Т. 3. – С. 18-22. 5. Chan J.F., Yip C.C., To K.K., Tang T.H., Wong S.C., Leung K.H., Fung A.Y., Ng A.C., Zou Z., Tsoi H.W., Choi G.K., Tam A.R., Cheng V.C., Chan K.H., Tsang O.T., Yuen K.Y. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. J. Clin. Microbiol., 2020, vol. 58, no. 5: e00310-20. doi: 10.1128/JCM.00310-20 6. Hu E. COVID-19 testing: challenges, limitations and suggestions for improvement. Preprints 2020: 2020040155. doi: 10.20944/ preprints202004.0155.v1 7. Ibarrondo FJ, Fulcher JA, Goodman-Meza D, Elliott J, Hofmann C, Hausner MA, Ferbas KG, Tobin NH, Aldrovandi GM, Yang OO. Rapid decay of anti-SARS-CoV-2 antibodies in persons with mild Covid-19. The New England Journal of Medicine 2020 Sep;383(11):1085-7. 10. Patel MM, Thornburg NJ, Stubblefield WB, Talbot HK, Coughlin MM, Feldstein LR, Self WH. Change in antibodies to SARS-CoV-2 over 60 days among health care personnel in Nashville, Tennessee. JAMA 2020 Sep;324(17):1781-2. 8. Loeffelholz M.J., Tang Y.W. Laboratory diagnosis of emerging human coronavirus infections — the state of the art. Emerg. Microbes Infect., 2020, vol. 9, no. 1, pp. 747–756. doi: 10.1080/22221751.2020.1745095 9. Makatsariya A.D., Grigorieva K.N., Mingalimov M.A. Coronavirus disease (COVID-19) and disseminated intravascular coagulation. [Koronavirusnaya infekciya (COVID-19) i sindrom disseminirovannogo vnutrisosudistogo svertyvaniya]. Akusherstvo, ginekologiya i reprodukciya. 2020;14(2):[accepted manuscript]. (In Russ.). DOI: 10.17749/2313-7347.132. 10. Naimova N. S. et al. Features of coagulation and cellular hemostasis in rheumatoid arthritis in patients with cardio-vascular pathology //Asian Journal of Multidimensional Research (AJMR). – 2019. – Т. 8. – №. 2. – С. 157-164. 11. Naimova S. A. Principles of early diagnosis of kidney damage in patients of rheumatoid arthritis and ankylosing spondiloarthritis //British Medical Journal. – 2021. – Т. 1. – №. 1. 12. Rajgor D.D., Lee M.H., Archuleta S. et al. The many estimates of the COVID-19 case fatality rate. Lancet Infect Dis. 2020 Mar 27. pii: S1473-3099(20)30244-9. DOI: 10.1016/S1473-3099(20)30244-9. 13. Wang F., Hou H., Luo Y. et al. The laboratory tests and host immunity of COVID-19 patients with different severity of illness. JCI Insight. 2020. DOI: 10.1172/jci.insight.137799. 14. Weitz J.S., Beckett S. J., Coenen A.R. et al. Intervention serology and interaction substitution: modeling the role of ‘shield immunity’ in reducing COVID-19 epidemic spread. MedRxiv. 2020. DOI: 10.1101/2020.04.01.20049767