Biomeditsina va amaliyot jurnali, 2023 №1


Subject of the article

MELANOMA OF THE SKIN AND PREGNANCY (187-196)

Authors

Shakhanova Sh Shakhnoza, Rakhimov M. Nodir, Tursunov S. Sherali, Ergashev E. Abdulatif, Davronov E.Eshboy

Institution

Samarkand State Medical University

Abstract

The effect of pregnancy on the clinical course and prognosis in delanomas is the subject of contradictory observations and conclusions. There are known data on the effect of certain hormones on the pigment system and the relationship between sex hormones and malignant melanoma. It was found that there are special receptors for estrogens in the cytoplasm of primary melanoma cells (Bruli S., 2010). In the United States, it is possible to determine to what extent this is the case (Sadoff L. and others, 2013; Lerner L. et al., 2019). However, A.Adam. (2011) did not find a link between the use of hormonal contraceptives and the occurrence of melanoma. To.Sutherland. (2013) indicate an increase in hormone levels during pregnancy, and then a rapid decrease after childbirth

Key words

melanoma, skin, pregnancy

Literature

Aceves, C. The extrathyronine actions of iodine as antioxidant, apoptotic, and differentiation factor in various tissues / C.Aceves, B. Anguiano, G. Delgado // Thyroid.- 2013. - Vol.23, №8. - Р.938-46. doi: 10.1089/thy.2012.0579. 2. Addor, F.A.S. Beyond photoaging: additional factors involved in the process of skin aging. / Addor, F.A.S. // Clin Cosmet Investig Dermatol. - 2018. - Vol.20, №11. -Р.437-443. doi: 10.2147/CCID.S177448. 3. Amaravadi, R. Mouse models address key concerns regarding autophagy inhibition in cancer therapy. / R.Amaravadi, J.Debnath // Cancer Discov. - 2014. -Vol.4, №8. - P.873-875. 4. American Cancer Society. Cancer Facts & Figures 2021. P. 24. Available at: https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/ cancer-factsfigures- 2021.html. 5. Banchereau J., Palucka A.K., Dhodapkar M., Burkeholder S., Taquet N., Rolland A., Taquet S., Coquery S., Wittkowski K.M., Bhardwaj N. Immune and clinical responses in patients with 􀁔􀁛􀁡􀁟􀁘􀁗􀁛􀁩􀁛􀁠􀁓􀀃􀁕􀁓􀀃􀁓􀁟􀁓􀁞􀁛􀇜􀁥􀀃􀁙􀁦􀁣􀁠􀁓􀁞􀁛􀀃􀀃􀂬􀀃􀀃􀁙􀁦􀁣􀁠􀁓􀁞􀀃􀁔􀁛􀁡􀁟􀁘􀁗􀁛􀁩􀁛􀁠􀁮􀀃􀁛􀀃􀁢􀁣􀁓􀁝􀁥􀁛􀁝􀁛􀀃􀀃􀂬􀀃􀀃􀀉􀀎􀀔􀀑􀀍􀉮􀀋􀀃􀀎􀀅􀀃􀉸􀀈􀀎􀀌􀀄􀉖􀀈􀉹􀀈􀀍􀀄􀀃􀉮􀀍􀉖􀀃􀀏􀀑􀉮􀉹􀀓􀀈􀉹􀀄 №1 | 2023 195 metastatic melanoma to CD34+ progenitor-derived dendritic cell vaccine. Cancer Res. 2001; 61 (17): 6451-8. 6. Bandovkina, V.A. Effect of estrogens on growth factors in melanoma and nevi / V.A. Bandovkina, O.I. Kit, E.M. Frantsiyants, V.A. Sustretov et al. // ASCO Annual Meeting J. Clin. Oncol. - 2018. - Vol. 36, Suppl. - abstr. e21628. 7. Ben-Kasus T., Schechter B., Lavi S., Yarden Y., Sela M. Persistent elimination of ErbB- 2/HER2-overexpressing tumors using combinations of monoclonal antibodies: relevance of receptor endocytosis. Proc Natl Acad Sci U S A. 2009 Mar 3; 106 (9): 3294-9. doi: 10.1073/ pnas.0812059106. 8. Cancer Immunol Immunother. 2010; 59 (6): 863-73. doi: 10.1007/ s00262-009-0811-7. 9. Capatina A.L., Lagos D., Brackenbury W.J. Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges. In: Reviews of Physiology, Biochemistry and Pharmacology. Berlin, Heidelberg: Springer; 2020: 1-43. 10. Denat, L. Melanocytes as instigators and victims of oxidative stress. / L. Denat, A.L. Kadekaro, L. Marrot, S.A. Leachman et al. // J Invest Dermatol. - 2014. - Vol.134, №6. - P.1512-1518. doi: 10.1038/jid.2014.65. 11. Eells J.T., Wong-Riley M.T., VerHoeve J. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004; 4 (5-6): 559- 567. 12. El-Safadi S., Estel R., Mayser P., Muenstedt K. Primary malignant melanoma of the urethra: a systematic analysis of the current literature. Arch Gynecol Obstet 2014;289(5):935-43. DOI: 10.1007/s00404-013-3130-3. 13. Pesapane F. et al. Imaging diagnosis of metastatic breast cancer //Insights into imaging. – 2020. – Т. 11. – №. 1. – С. 1-14. 14. Robert C., Thomas L., Bondarenko I., ODay S., Weber J., Garbe C., Lebbe C., Baurain J.F., Testori A., Grob J.J., Davidson N., Richards J., Maio M., Hauschild A., Miller W.H.Jr., Gascon P., Lotem M., Harmankaya K., Ibrahim R., Francis S., Chen T.T., Humphrey R., Hoos A., Wolchok J.D. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011; 364 (26): 2517-26. doi: 10.1056/NE-JMoa1104621. 15. Shavkatovna, S. S., Maxammatkulovich, R. N., & qizi, S. N. A. (2022). Breast Pathology in Adolescent Girls. Central Asian Journal of Medical and Natural Science, 3(3), 66-71. https://doi.org/10.17605/OSF.IO/MVD63 16. Shaxanova Sh Sh, Raximov N.M. Improving the combined treatment tactics of many osteogen metastases of malignant tumors of the urinary-body system. Web of Scientist: International Scientific Research Journal 2022/4/30, P 1145-1149. 17. Бандовкина, В.А. Нейроэндокринные и метаболические аспекты патогенеза злокачественного роста перевивной меланомы В16 / В.А. Бандовкина, О.И. Кит, Е.М. Франциянц, С.С. Тодоров // Злокачественные опухоли. - 2015. - №4, спец вып. 2. - С.266- 267. 18. Гриднева Я.В. Меланома уретры. Онкоурология 2005;1(3):66-70. [Gridneva Ya.V. Urethral melanoma. Onkourologiya = Cancer Urology 2005;1(3):66-70. (In Russ.)]. 19. Злокачественные новообразования в России в 2019 году (заболеваемость и смертность). 20. Клинические рекомендации. Меланома кожи и слизистых оболочек. / Российское общество клинических онкологов // 2021. 21. Поляков А.П., Мордовский А.В. Современная стратегия терапии метастатической BRAF-положительной меланомы кожи. Фарматека 2020;11:14-20. [Polyakov A.P., Mordovskiy A.V. Current therapy strategy for metastatic BRAF-positive cutaneous melanoma. Farmateka = Pharmateca 2020;11:14-20 (In Russ.)]. DOI: 10.18565/pharmateca.2020.11.14- 20. 22. Шаханова Ш.Ш., Рахимов Н.М., Эсанкулова Б.С., Корабоев Ф.Т., Хакимов А.А. Осложнения таргетной терапии при лечении почечно-клеточного рака с метастазами в костях и лимфоузлах. Журнал вестник врача 2021, Том 1, Номер 2 (99), Р116-120. 􀁔􀁛􀁡􀁟􀁘􀁗􀁛􀁩􀁛􀁠􀁓􀀃􀁕􀁓􀀃􀁓􀁟􀁓􀁞􀁛􀇜􀁥􀀃􀁙􀁦􀁣􀁠􀁓􀁞􀁛􀀃􀀃􀂬􀀃􀀃􀁙􀁦􀁣􀁠􀁓􀁞􀀃􀁔􀁛􀁡􀁟􀁘􀁗􀁛􀁩􀁛􀁠􀁮􀀃􀁛􀀃􀁢􀁣􀁓􀁝􀁥􀁛􀁝􀁛􀀃􀀃􀂬􀀃􀀃􀀉􀀎􀀔􀀑􀀍􀉮􀀋􀀃􀀎􀀅􀀃􀉸􀀈􀀎􀀌􀀄􀉖􀀈􀉹􀀈􀀍􀀄􀀃􀉮􀀍􀉖􀀃􀀏􀀑􀉮􀉹􀀓􀀈􀉹􀀄 №1 | 2023 196 23. Шаханова Ш.Ш., Рахимов Н.М. Мультимодальный подход к лечению множественных остеогеных метастазов рака почки и предстательной железы. Клиническая и экспериментальная онкология 2020, №4 Стр 50-56. 24. Шаханова Ш.Ш., Рахимов Н.М., Корабоев Ф.Т. Buyrаk vа prostаtа bezi koʼplаb osteogen metаstаzlаridа dаvolаsh sаmаrаdorligini oshirish. Журнал Репродуктивного Здоровья и Уро- Нефрологических Исследований 2022/6/27, Том 3, Номер 2. 25. Rizaev, J. A., and A. I. Khazratov. "Цитоструктурное изменение слизистой оболочке полости рта при раке толстой кишки." Journal of Biomedicine and Practice 6.5 (2020). 26. Ризаев Ж. А., Хазратов А. И. Канцерогенное влияние 1, 2–диметилгидразина на организм в целом //Биология. – 2020. – Т. 1. – С. 116. 27. Rizaev J. A., Maeda H., Khramova N. V. Plastic surgery for the defects in maxillofacial region after surgical resection of benign tumors //Annals of Cancer Research and Therapy. – 2019. – Т. 27. – №. 1. – С. 22-23. 28. Rizaev Jasur, Norbutayev Alisher, Murtazayev Alisher. Modern methods for detecting oral cavity defects in hemoblastosis, detecting the degree of damage and prediction of the clinical current. Journal of Biomedicine and Practice. 2021, vol. 6, issue 5, pp. 45-51