Biomeditsina va amaliyot jurnali, 2022 №6
Subject of the article
THE SIGNIFICANCE OF THE G681A ALLELIC POLYMORPHISM OF THE CYP2C19 GENE IN THE GENESIS OF MALE FERTILITY DISORDERS (25-31)
Authors
Irgashev S. Dilmurad, Gasanova S. Shakhina, Boboev T. Kodirjon
Institution
RSSPMCH MoH RUz
Abstract
The role of the G681A polymorphism of the CYP2C19 gene in the formation of male infertility was analyzed. The study was conducted on a sample of 140 patients with various clinical forms of male infertility and 155 conditionally healthy fertile men. Despite the involvement of this locus in the regulation of the synthesis of sex hormones, especially androgens, the carriage of an unfavorable variant of this gene does not have an independent phenotypic effect on male fertility disorders, which allows us to conclude that this gene does not play an independent role in the genesis of male fertility disorders
Key words
male infertility, G681A polymorphism of the CYP2C19 gene, allele, genotype
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