Biomeditsina va amaliyot jurnali, 2022 №4
Subject of the article
NON-ALCOHOLIC FATTY LIVER DISEASE, MODERN VIEWS (310-317)
Authors
NON-ALCOHOLIC FATTY LIVER DISEASE, MODERN VIEWS
Institution
Самарқанд Давлат тиббиёт университети
Abstract
Ushbu maqolada polietiologik kasallik hisoblangan jigarning noalkogol yog’ xastaligi (JNYoX)ga doir muammolarning adabiyotlar bo’yicha tahlili bayon etilgan. Hayvon yog'lari va oson hazm bo'ladigan uglevodlarga boy oziq-ovqat mahsulotlarini ortiqcha iste'mol qilish ko'p miqdorda erkin yog’ kislotalarining (EYoK) oshqozon-ichak traktidan qonga, so'ngra to'qimalarda yig’ilishiga olib keladi, natijada jigarda steatozning rivojlanishi kuzatiladi. Yog' to'qimalari tomonidan faol ravishda ajralib chiqayotgan yallig'lanish mediatorlari gepatotsit membranalarini bevosita shikastlaydi, buning natijasida jigarda fibroz to'qimalarning to'planishi kuzatiladi. JNYoX ning asosiy xususiyati ko’pincha simptomsiz kechib, kasallik metabolik sindromli bemorlarda o'tkazilgan laboratoriya yoki instrumental tekshiruvlar asosida tasodifan aniqlanadi. Jigarning noalkogol yog’ xastaligi juda keng tarqalgan patologiya bo'lib, uning patogenezi mexanizmlarini chuqur o'rganishni va uning murakkab shakllarini (steatohepatit, fibroz, siroz) aniqlash va baholashning eng maqbul noinvaziv usullarini izlashni talab qiladi. Kalit so’zlar: Jigarning noalkogol yog’ xastaligi, steatoz, steatogepatit, jigar tsirrozi, diagnostika.
Key words
Kalit so’zlar: Jigarning noalkogol yog’ xastaligi, steatoz, steatogepatit, jigar tsirrozi, diagnostika.
Literature
1. Selivyorstov P. V. Nealkogol'naya jirovaya bolezn' pecheni: ot teorii k praktike //Arxiv' vnutrenney medisini.– 2015. – №. 1. – С. 19-26. 2. Lazebnik L. B. i dr. Nealkogol'naya jirovaya bolezn' pecheni: klinika, diagnostika, lechenie (rekomendasii dlya terapevtov, 2-ya versiya) // Eksperimental'naya i klinicheskaya gastroenterologiya. – 2017. – №. 2 (138). 3. Mishina Ye.E., Mayorov A.Yu., Bogomolov P.O., Masievich M.V., Kokina K.Yu., Bogolyubova A.V. Nealkogol'naya jirovaya bolezn' pecheni: prichina ili sledstvie insulinorezistentnosti? Saxarniy diabet.2017;20(5):335-343. https://doi.org/10.14341/DM9372 4. Starodubova A. V. Izbitochnaya mass tela i ojirenie kak faktori riska nealkogol'noy jirovoy bolezni pecheni //Arxiv' vnutrenney medisini. – 2014. – №. 5. – С. 10-20. 5. Pal'sev A. I. i dr. Nealkogol'naya jirovaya bolezn' pecheni: vozrastnie osobennosti, novoe v patogeneticheskoy terapii //Eksperimental'naya i klinicheskaya gastroenterologiya.– 2009. – №. 8. – С. 19-25. 6. Livzan M. A. i dr. Nealkogol'naya jirovaya bolezn' pecheni u lis s abdominal'nim tipom ojireniya //Dokazatelnaya Kardiologia.– 2014. – №. 4. 7. Kiseleva Ye. V., Demidova T. Yu. Nealkogol'naya jirovaya bolezn' pecheni i saxarniy diabet 2 tipa: problema sopryajennosti i etapnosti razvitiya //Ojirenie i metabolizm. 2021. – Т. 18. – №. 3. – С. 313-319. 8. Livzan M. A. i dr. Nealkogol'naya jirovaya bolezn' pecheni: kak izbejat' oshibok v kurasii pasientov //Effektivnaya farmakoterapiya.– 2021. – Т