Kardiorespirator tadqiqotlar jurnali 1.(2020)
Subject of the article
NAFAS OLISH TIZIMINING SIL KASALLIGINI KOMPLEKS DAVOLASH SAMARADORLIGIGA BEDAKVILINNING TA'SIRI (77-80)
Authors
Mamatova N.Т.
Institution
Samarqand davlat tibbiyot instituti
Abstract
Ko'p dorilarga chidamli sil (MDR-TB) bilan og'rigan bemorlarni davolash muammosi 2000 yildandan buyon ftiziatriya sohasida dunyodagi etakchi muammolardan hisoblanadi. 2013 yilda Jahon sog'liqni saqlash tashkiloti yangi antimikobakterial dori sifatida yangi ta'sir mexanizmiga ega bo'lgan preparatni, ya'ni bedakvilinni tasdiqladi. Ishning maqsadi bedakvilin dori vositasini tayinlash orqali nafas tizimi silini davolashning klinik samaradorligini oshirish imkoniyatlarini baholash edi. Taqdim etilgan natijalar 2017 yildan 2020 yilgacha Samarqand viloyat silga qarshi kurashish dispanserida davolangan keng dorilarga chidamli nafas olish tizimi sili bilan og'rigan 58 nafar bemorlarni dinamik kuzatish va davolash asosida olingan. Bedakvilin dori vositasini qo'llashda ijobiy samaradorlik (mikobakteriyalar ajratishning to'xtatilishi va emirilish bo'shlig'ining yopilishi) yallig'langan o'pka sili va tarqoq o'pka sili bilan kasallangan birinchi marta aniqlangan bemorlarda qayd etilgan. Bedakvilin dori vositasini ilgari qabul qilmagan bemorlarga tavsiya etish kasallikning klinik belgilari kamayishiga, yallig'lanish jarayoni va emirilish bo'shliqlarining hajmi sezilarli darajada kichrayishiga imkon beradi.
Key words
ko'p dorilarga chidamli sil, keng dorilarga chidamli sil, bedakvilin, davolash, nafas olish tizimi
Literature
1. Инструкция по применению лекарственного препарата для медицинского. применения Сиртуро (Sirturo®). Регистрационный номер: ЛП-002281. [Электронный ресурс] URL: http://www.ros-med.info/reestrls/ info. php?action= info &id=26223. (Дата обращения 20.04.2015 г.). 2. Маматова Н.Т., Ходжаева С.А. Выявление туберкулёза лёгких у больных с психическими расстройствами. // Журнал молодёжный инновационный вестник. 2018. №1(7). стр. 68. 3. Маматова Н.Т., Ходжаева С.А. Отрицательные социальные факторы и их влияние на возникновение туберкулёза у детей. // Журнал молодёжный инновационный вестник. 2018. №1(7). стр. 67. 4. Dheda K., Esmail A., Limberis J., Maartens G. Selected questions and controversies about bedaquiline: a view from the field // Int. J. Tuberc. Lung Dis. - Vol. 20, № 12. - R. S24-S32. 5. Dheda K., Migliori G.B. The global rise of extensively drug resistant tuberculosis: is the time to bring back sanatoria now overdue// www.thelancet.com Published online October 26, 2011 DOI:10.1016/S0140-6736(11)61062-33. 6. Global tuberculosis report 2018, Geneva: World Health Organization, 2018; 95-96 7. HPCA. Guidelines for providing palliative care to patients with tuberculosis. Hospice Palliative Care Association; South Africa, 2011. p.1-141. 8. HPCA. Guidelines for providing palliative care to patients with tuberculosis. Hospice Palliative Care Association; South Africa, 2011. p.1-141nition/en/ Accessed April 2012. 9. Pym A. S., Diacon A. H., Tang S. J., Conradie F., Danilovits M., Chuchottaworn C., Vasilyeva I., Andries K., Bakare N., de Marez T., Haxaire-Theeuwes M., Lounis N., Meyvisch P., Van Baelen B., van Heeswijk R. P., Dannemann B. TMC207- C209 Study Group. Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis // Eur. Respir. J. ‒ 2016. ‒ Vol. 47, № 2. ‒ R. 564-574. doi: 10.1183/13993003.00724-2015. 10. Senthilingam M., Pietersen E.Mc., Nerney R, Te Riele J., Sedres P., Wilson R., Dheda K. Lifestyle, attitudes and needs of uncured XDR-TB patients living in the communities of South Africa: a qualitative study. Trop Med Int Health., 2015 Sep;20(9):1155-1161. doi: 10.1111/tmi.12532.