Журнал кардиореспираторных исследований 2026. №3
Subject of the article
Arterial gipertenziyali bemorlarda arterial bosimning sutkalik profili va chap qorincha remodellanishining o‘ziga xos xususiyatlari (120-123)
Authors
Yarmukhamedova S.X.
Institution
Samarqand davlat tibbiyot universiteti
Abstract
Tadqiqot maqsadi: arterial gipertenziyali bemorlarda arterial bosimning sutkalik profili xususiyatlarini o‘rganish hamda arterial bosimni sutkalik monitoring qilish ko‘rsatkichlari bilan miokardning strukturaviy-funksional o‘zgarishlari o‘rtasidagi o‘zaro bog‘liqlikni baholash. Materiallar va tadqiqot usullari: arterial gipertenziya bilan og‘rigan 30–75 yoshdagi 560 nafar bemor tekshirildi, ularning o‘rtacha yoshi 56,4±10,8 yoshni tashkil etdi. Barcha bemorlarda arterial bosimning sutkalik monitoringi (ABSM), standart exokardiografiya va to‘qima Dopplerexokardiografiyasi o‘tkazildi. ABSM ma’lumotlari asosida sistolik va diastolik arterial bosimning o‘rtacha sutkalik, kunduzgi va tungi qiymatlari, shuningdek arterial bosimning tunda pasayish xususiyati baholandi. Sirkad profiliga ko‘ra bemorlar dipper, non-dipper va night-peaker turlariga ajratildi. Yurakning strukturaviy-funksional holati qorinchalararo to‘siq va chap qorincha orqa devori qalinligi, devorning nisbiy qalinligi (DNQ), chap qorincha miokardi massasi va uning indeksi (ChQMMI) bo‘yicha baholandi. Diastolik funksiya e′ va E/e′ ko‘rsatkichlari asosida baholandi. O‘zaro bog‘liqliklarni tahlil qilish uchun korrelyatsion tahlil qo‘llanildi. Tadqiqot natijalari: o‘rtacha sutkalik SAB 152±17 mm sim. ust., DAB 94±10 mm sim. ust.; kunduzgi SAB 158±18 mm sim. ust., kunduzgi DAB 98±11 mm sim. ust.; tungi SAB 142±16 mm sim. ust., tungi DAB 86±19 mm sim. ust. ni tashkil etdi. Dipper profili 213 (38,0%) bemorda, non-dipper 235 (42,0%) bemorda, night-peaker 112 (20,0%) bemorda qayd etildi. Noqulay sirkad profillar 347 (62,0%) bemorda aniqlandi. ChQMMI 118±24 g/m², DNQ 0,46±0,07 ni tashkil etdi; chap qorincha geometriyasining patologik turlari 76% bemorda aniqlandi. O‘rtacha sutkalik SAB bilan ChQMMI o‘rtasida statistik ahamiyatli musbat korrelyatsiya qayd etildi (r=0,44; p<0,001). Tungi SAB va DAB ning yuqori qiymatlari hamda arterial bosimning fiziologik tungi pasayishining buzilishi e′ ning pasayishi va E/e′ nisbatining oshishi bilan bog‘liq bo‘ldi. Xulosa: arterial gipertenziyali bemorlarda arterial bosim sirkad profilining buzilishlari yuqori darajada uchraydi. Sutkalik gemodinamik yuklama chap qorinchaning strukturaviy remodellanishi bilan, tungi profil buzilishlari esa diastolik funksiyaning yomonlashishi bilan bog‘liq.
Key words
arterial gipertenziya, arterial bosimning sutkalik monitoringi, ABSM, non-dipper, night-peaker, miokard remodellanishi, chap qorincha gipertrofiyasi, diastolik disfunksiya
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