Журнал кардиореспираторных исследований 2026. №2/2

Subject of the article

Latent sil infeksiyasi bo'lgan bolalarda D vitamini tanqisligi (10-13)

Authors

D.N. Adjablayeva

Institution

Samarqand davlat tibbiyot universiteti

Abstract

Ushbu tadqiqotda latent sil infeksiyasiga ega bolalarda vitamin D darajasi va kalsiy‑fosfor almashinuvi ko‘rsatkichlari baholandi. Tadqiqotga 1–17 yoshli 40 nafar bola jalb etildi, ular tuberkulin sinoviga patologik reaksiya ko‘rsatgan, ammo aktiv sil kasalligi klinik va rentgenologik.belgilarisiz kechgan. Barcha bolalarga federal klinik tavsiyalarga muvofiq profilaktik davolash tayinlangan. Laborator tahlillar natijasida 92,5% bolada 25(OH)D darajasi adekvat me’yordan past ekani aniqlandi. Ayniqsa, 7–17 yoshli bolalarda vitamin D tanqisligi statistik jihatdan ko‘proq uchradi. Umumiy va ionlashgan kalsiy darajalari me’yorda saqlandi, ammo 87,5% bolada ishqoriy fosfataza faolligi oshganligi qayd etildi. Bu holat tuberkulyozga qarshi preparatlar qabul qilish yoki o‘smirlik davridagi suyak metabolizmi bilan bog‘liq bo‘lishi mumkin. Olingan ma’lumotlar latent sil infeksiyasiga ega bolalarda vitamin D yetishmovchiligi yuqori darajada tarqalganini ko‘rsatadi. Shuningdek, profilaktik davolash jarayonida vitamin D darajasini muntazam nazorat qilish va zarur hollarda korreksiya qilish muhim ahamiyatga ega. 87,5% bolada ishqoriy fosfataza faolligi oshganligi qayd etildi, bu tuberkulyozga qarshi preparatlar qabul qilish yoki o‘smirlik davridagi suyak metabolizmi bilan bog‘liq bo‘lishi mumkin

Key words

bolalar, latent sil infeksiyasi, vitamin D, kalsiy almashinuvi, immunodiagnostika.

Literature

1. Adzhablaeva D.N., Khodzhaeva S.A. Quality of life in children with latent tuberculosis infection. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(6):83-87. (In Russ.) https://doi.org/10.21508/1027- 4065-2021-66-6-83-87 2. Adzhablayeva D.N. Main epidemiological indicators of respiratory tuberculosis among children and adolescents in the Samarkand region: the state of the problem and possible ways to resolve it. Universum: medicine and pharmacology. 2014; 9 (10). 2. (in Russ). 3. Aksenova V. A., Baryshnikova L. A., Klevno N. I., Kudlay D. A. Screening of children and adolescents for tuberculosis infection in Russia - past, present, future. Tub. and lung diseases. 2019; 97(9), 59-67. (In Russ). 4. Global tuberculosis report 2023; 978924008385eng.pdf (who.int) 5. Goletti D. et al. Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease. Respirology. 2018; 23(5). 455-466. 6. Khodzhaeva S., Adzhablayeva D., Mamatova N. Current issues of genital tuberculosis in women and men. The influence of the tuberculosis process on fertility. Journal of the Doctor's Bulletin. 2011; 1(2). 151-153. (In Russ). 7. Latorre I., Domínguez J. Dormancy antigens as biomarkers of latent tuberculosis infection. Biomedicine. 2015; 2(8). 790-791. 8. Ovsyankina E.S. and others. Risk factors for the development of tuberculosis in children with and without contact with a patient with tuberculosis. Tuberculosis and Lung Diseases. 2014; 10. 20-23.