Журнал кардиореспираторных исследований 2025. №2/2

Subject of the article

IMMUNOLOGICAL ASPECTS OF RHEUMATOLOGIC DISEASES AND APPROACHES TO THEIR THERAPY (77-83)

Authors

Babamuradova Zarrina Bakhtiyarovna

Institution

Samarkand State Medical University

Abstract

As of today, according to the health organization, rheumatological diseases are one of the leading causes of disability worldwide. The role of polymorphic genes in the autoimmune system (IL17A, IL17F, IL23R) and the cytokine system (TNFα, IL 1β, IL4, IL6, IL10) in the differential clinical course and severity of RD, as well as the correlation of polymorphic cytokine genes IL1β, IL6, IL17A, TNFα with clinical symptoms, has not been studied. The aim of the study is to investigate the characteristics of the immunological status and to develop differentiated approaches to the treatment of rheumatological diseases. A total of 379 patients with RD were examined and divided into several subgroups, along with 98 practically healthy individuals who voluntarily agreed to participate in the study. The results showed that after the application of levilimab, the level of pro-inflammatory cytokines decreased by 1.4 times, compared to methotrexate treatment. Thus, the homozygous state of the G allele in the phenotype of a patient with RA, ensuring a high level of IL-17A production, contributes to the good effectiveness of biologic therapy (GIBP).

Key words

rheumatological diseases, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, cytokines, autoimmune inflammation, genetically engineered biological drugs.

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