Журнал кардиореспираторных исследований 2025. №2/2

Subject of the article

YOSHLARDA AZOT OKSIDI BILAN SURUNKALI INTOKSIKATSIYASI NATIJASIDA V12 TANQISLIGI MIYELOPOLINEYROPATIYASINING KELIB CHIQISHI (65-71)

Authors

Xurramov Baxtiyor Shodiyevich, Mamatkulova Feruza Xaydarovna, Davronov Temur Sobirovich, Axmedov Sanjar Baxadirovich, Esergapov Bobur Alisher o‘g‘li

Institution

Samarqand Davlat Tibbiyot universiteti, Samarqand viloyat ko‘p tarmoqli tibbiyot markazi

Abstract

Hozirgi vaqtda azot oksidini ("kuldiruvchi gaz") suiste’mol qilish muammosi dolzarb bo‘lib qoldi, chunki yoshlar orasida ushbu turdagi "o‘yin-kulgi" mashhurligi o‘sdi. Azot oksidining muntazam, hatto qisqa muddatli ingalatsiyasi muhim metabolik jarayonlar uchun muhim kofaktor bo‘lgan B12 vitamini yetishmovchiligini rivojlanish ehtimolini oshiradi. Maqolada azot oksidini suiiste’mol qiladigan yoshlarda nevrologik kasalliklar rivojlanishining 2 ta klinik kuzatuvi keltirilgan. Bunday sharoitlarni tashxislashning qiyinchiliklari, terapevtik taktika va prognozi ko‘rib chiqiladi. B12 tanqisligi anemiyasi (megaloblastik anemiya,Addison-Biermer), progressiv giperkromik, makrositik bilan tavsiflanadi anemiya, neytrofil yadrolarining gipersegmentatsiyasi, megaloblastik eritropoez va suyak iligidagi boshqa gematopoetik mikroblarning morfologik anomaliyalari; farqli o'laroq boshqa anemiyalardan, B12 tanqisligi kamqonligi ko'pincha rivojlanishi bilan bog'liq patologik psixonevrologik alomatlar (funikulyar miyeloz)

Key words

azot oksidi, kulgili gaz, miyelopolineyropatiya , funikulyor miyeloz, vitamin B12 etishmovchiligi, siyanokobalamin, gomosistein, metilmalon kislotasi

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