Журнал кардиореспираторных исследований 2025. №2/2
Subject of the article
BUYRAKLARNING ERTA JAROHATLANISH BIOMARKERLARI: ZAMONAVIY LABORATOR YONDASHUVLAR (57-60)
Authors
Xamrayev Xamza Xamidullayevich, Sultonov Ilhom Islomovich, Xamrayev Botirjon Egamqulovich, Normurodov Jahongir Yo'ldoshovich
Institution
Samarqand davlat tibbiyot universiteti
Abstract
Rezyume: Ushbu maqolada buyraklarning erta shikastlanishini aniqlash bo‘yicha zamonaviy laboratoriya yondashuvlari ko‘rib chiqiladi, ayniqsa yuqori sezuvchanlik va o‘ziga xoslikka ega bo‘lgan biomarkerlarga e’tibor qaratiladi. An’anaviy markerlar, masalan, kreatinin va siydik mochevinasi, kasallikning dastlabki bosqichlarida cheklangan diagnostik qiymatga ega. Shu sababli, mikroRNK, Cystatin C, NGAL(Neutrophil Gelatinase-Associated Lipocalin), KIM-1(Kidney Injury Molecule-1) va L-FABP (Liver- Type Fatty Acid-Binding Protein) kabi yangi molekulyar biomarkerlar faol o‘rganilmoqda, chunki ular klinik simptomlar paydo bo‘lishidan ancha oldin patologik o‘zgarishlarni aniqlash imkonini beradi. O‘tkazilgan tahlillar shuni ko‘rsatdiki, bir nechta biomarkerlarni birgalikda qo‘llash diagnostik aniqroq natijalarga olib keladi va buyrak kasalliklarining rivojlanishini oldindan bashorat qilish imkonini beradi. Ushbu yo‘nalishda keyingi tadqiqotlar biomarkerlarni aniqlash usullarini standartlashtirish va ularni klinik amaliyotga joriy etish uchun zarur hisoblanadi.
Key words
biomarkerlar, o‘tkir buyrak shikastlanishi, NGAL, Cystatin C, KIM-1, laboratoriya diagnostikasi.
Literature
1. Berdikulov IF, Yulaeva IA, Isomadinova LK. Laboratory methods for assessing kidney function: new biomarkers and standards. Journal of New Century Innovations. 2023;49(2):112-116. (in Russ). 2. Iskenderov BG, Sisina ON, Timofeeva NA. Prognostic value of determining kidney injury biomarkers in patients undergoing correction of valvular heart defects complicated by acute kidney injury. CardioSomatika. 2015;6(1-1):44-45. (in Russ). 3. Ivanov AA, Petrov PP, Sidorov KK. Biomarkers of acute kidney injury. Bulletin of Transplantology and Artificial Organs. 2016;18(2):45-52. (in Russ). 4. Ivanova EA, Kuznetsova EV, Smirnova EV. The role of biomarkers in the diagnosis of early kidney injury in patients with chronic kidney disease. Nephrology. 2020;24(3):45-52. (in Russ). 5. Klimova EA, Sidorova MV, Petrova OV. Modern biomarkers of kidney injury in pediatrics. Nephrology and Dialysis. 2019;21(2):156-162. (in Russ). 6. Kuznetsova EV, Smirnova EV, Ivanova EA. Biomarkers of acute kidney injury: modern diagnostic possibilities. Therapeutic Archive. 2014;86(6):44-52. (in Russ). 7. Shoira, Khusinova. "FEATURES OF THE COURSE OF DISEASES OF THE DIGESTIVE TRACT IN THE ELDERLY." International journal of artificial intelligence 4.03 (2024): 370-373. 8. Хусинова, Ш. А., Н. А. Нармухамедова, and Н. Э. Юлдашова. "СОВРЕМЕННЫЕ ПРОБЛЕМЫ ПРОФИЛАКТИКИ НЕИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ: Хусинова ША, Нармухамедова НА, Юлдашова НЭ." Лучшие интеллектуальные исследования 22.2 (2024): 70-76. 9. Akbarovna, Khusinova Shoira, and Narmukhamedova Nazira Azizovna. "Increasing the Adherence of Patients with Arterial Hypertension to Treatment." NATURALISTA CAMPANO 28.1 (2024): 3043-3047. 10. Petrova OV, Sidorova MV, Klimova EA. New biomarkers of kidney injury and their use in minimally invasive treatment of urolithiasis. Experimental and Clinical Urology. 2018;4:60-65. (in Russ). 11. Petrov PP, Ivanov AA, Sidorov KK. Modern biomarkers of acute kidney injury. Pharmacoeconomics: Theory and Practice. 2021;9(1):45-52. (in Russ). 12. Sidorov KK, Ivanov AA, Petrov PP. NGAL and KIM-1 – early urinary biomarkers of nephrotoxicity in the treatment of oncological diseases. Modern Oncology. 2017;19(3):45-52. (in Russ). 13. Smirnova EV, Kuznetsova EV, Ivanova EA. Biomarkers of early kidney injury: literature review. National Interests: Priorities and Security. 2015;6(1):44-45. (in Russ).