Kardiorespirator tadqiqotlar jurnali. Maxsus son. 2022
Subject of the article
EFFICACY OF AMLODIPINE IN ARTERIAL HYPERTENSION COMBINED WITH TYPE 2 DIABETES MELLITUS (114-117)
Authors
Normatov M.B.
Institution
Samarkand State Medical Univercity
Abstract
The combination of AH and diabetes increases the risk of coronary heart disease, stroke, kidney failure by 2-3 times. Therefore, it is extremely important to recognize and diagnose both arterial hypertension and diabetes mellitus early, in order to prescribe the appropriate treatment in time and stop the development of severe vascular complications. On the ionic level, insulin affects the entry of calcium and sodium into the cell, which affect the contractility of vascular smooth muscle fibers. As a result of decreased insulin sensitivity, calcium influx into the cell increases and smooth muscle cell tension increases. In such patients, the response of coronary arteries to physiological stimuli is reduced (decreased ability to dilate), which leads to impaired microcirculation.
Key words
Arterial hypertension, amlodipine, type 2 diabetes mellitus
Literature
1. Aghababyan I.R., Sadykova Sh. Sh., Ruzieva A.A. Assessment of patients who suffered myocardial infarction complicated by chronic heart failure against the background of taking cardioprotectors // Advances in Science and Education. - 2020. - №. 2 (56). 2. Xabibovna Y. S., Buriboevich N. M. SOME FEATURES OF STRUCTURAL AND FUNCTIONAL CHANGES OF THE MYOCARDIAL IN PATIENTS WITH DIABETES MELLITUS WITH DIASTOLIC HEART FAILURE //E-Conference Globe. - 2021. - P. 208-211. 3. Habibovna Y. S. et al. Assessment of Structural and Functional Heart Changes in Patients with Diabetes Mellitus with Diastolic Heart Failure //Annals of the Romanian Society for Cell Biology. - 2021. - С. 12154-12159. 4. Alisherovna M. K., Erkinovna Z. K., Tatlibayevich S. Y. Liver Diseases in Pregnant Women, Principles of Treatment //Eurasian Research Bulletin. - 2022. - Т. 4. - С. 48-51. 5. Yarmukhamedova S. et al. Značilnosti diastolične disfunkcije desnega prekata pri bolnikih s hipertonično boleznijo //Journal of Advanced Medical and Dental Sciences Research. - 2020. - Т. 8. - №. 9. - С. 74-77. 6. Alisherovna K. M., Davranovna M. H., Nizametdinovich K. S. Chronic Heart Failure in Women //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. - 2022. - Vol. 2. - No. 7. - P. 21-25. 7. Alisherovna K. M., Djamshedovna K. D., Kayumovna A. S. Evaluate the Quality of Life using the KDQOL-SFTM Questionnaire //CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES. - 2022. - Т. 2. - №. 7. - С. 26-31. 8. Yarmukhamedova S. et al. Study of intracardiac hemodynamic parameters and myocardial structural state during monotherapy of arterial hypertension patients with moxonidine // Journal of Advanced Medical and Dental Research. - 2020. - Т. 8. - №. 9. - С. 78-81. 9. Bekmuradova M.S., Makhmudova Kh. D., Nazarov F.Y. DIAGNOSTIC SIGNIFICANCE OF MOSCOW NATRIYURETIC PEPTYDESCRIPTION OF CHRONIC HEART DEFECTS //Scientific progress. - 2021. - Т. 2. - №. 1. - С. 810-814.