Kardiorespirator tadqiqotlar jurnali 4, 2021-yil


Subject of the article

BOLALARDA RETSIDIVLANUVCHI BRONXOOBSTRUKTIV SINDROM VA BRONXIAL ASTMANING EPIDEMIOLOGIK JIHATLARI (22-25)

Authors

Shavazi N.M., Atayeva M.S., G'aybullayev J.Sh., Xabibullayev Sh.F., Hakimov B.Sh.

Institution

Samarqand Davlat tibbiyot instituti, RSHTYOIMSF

Abstract

Zamonaviy sharoitda bronxial astma (BA) - nafas olish tizimining surunkali yallig'lanishiga asoslangan turli yoshdagi davrlarda klinik ko'rinishlarning o'zgarmasligini namoyish etadigan turli xil kasallikdir. Bronxial astmaning geterogenligini hisobga olsak kasallik fenotiplari tushunchasining paydo bo'lishiga olib keldi. "Fenotip" atamasi kasallikning klinik xususiyatlarini tasvirlash uchun ishlatiladi, fenotipik xususiyatlar klinik, biokimyoviy, immunologik va boshqa o'lchovli parametrlarni, organizmning har qanday xususiyatlari yoki belgilarni o'z ichaga oladi, fenotiplarning namoyon bo'lishi genotip va atrof-muhit ta'siri natijasida namoyon bo'ladi. Natijada bronxologik sindrom va bronxial astma tarqalishining natijasi yosh bolalarda bronxial astmani tekshirish va bronxoobstruksiya fenotiplarining yagona xalqaro tasnifi yo'qligi bilan bog'liq bo'lishi mumkin. Shunday qilib, respirator bronxoobstruktiv sindromini rivojlantirishi uchun eng muhim xavf omillarini aniqlash, ularni boshqarish imkonini beradi, respirator bronxoobstruktiv sindromini bronxial astmaga transformatsiya bo'lishini oldindan aytish imkonini beradi va individual davolashni tanlash, tadqiqotchilar va bronxoobstruktiv fenotiplarining yagona xalqaro tasnifi uchun muhim vazifaga aylandi

Key words

Bronxial astma, bronxo-obstruktiv sindrom, fenotip, geterogenlik

Literature

1. Evans, M. D. Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients/M. D. Evans, S. Esnault, L. C. Denlinger, N. N. Jarjour//Allergy and Clinical Immunology. – 2018. – V. 142, №. 2. – P. 415 - 423. 2. Fahy, J. V. Type 2 inflammation in asthma — present in most, absent in many /J. V. Fahy//Nat Rev Immunol. – 2015. – V. 15, № 1. – Р. 57– 65. doi: 10.1038/nri3786. 3. Fleming, L. Sputum inflammatory phenotypes are not stable in children with asthma / L. Fleming, L. Tsartsali, N. Wilson et al//Thorax. – 2012. – V.67. – Р. 675–681. 4. García-García M. L. Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study / M. L. García-García, C. Calvo, C. Rey, B. Díaz, M. Del, M. Molinero, F. Pozo, I. Casas//PLoS One. – 2017. – V. 12, № 3. – Р. 0173504.5. Garcia-Garcia, M. L. Role of viral coinfections in asthma development / M. L. Garcia-Garcia, C. Calvo, S. Ruiz, F. Pozo, V. del Pozo, L. Remedios, N. Exposito, A. Tellez, I. Casas//PLoS One. – 2017. – V. – 12, № 2. – Р. 0189083. doi: 10.1371/journal.pone.0189083 6. García-García, M. L. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis / M. L. García-García, C. Calvo, A. Moreira, J. A. Cañas, F. Pozo, B. Sastre, S. Quevedo, I. Casas, V. D. Pozo//Medicine (Baltimore). – 2017. – V. 96, № 18. – Р. 6787. 7. Gern, J. E. Patterns of immune development in urban preschoolers with recurrent wheeze and / J. E. Gern, A. Calatroni, K. F. Jaffee, H. Lynn, A. Dresen, W. Cruikshank, H. M. Lederman, H. A. Sampson, W. Shreffler, L. B. Bacharier, P. J. Gergen, D. R. Gold, M. Kattan, G.T. O'Connor, M. T. Sandel, R. A. Wood, G. R. Bloomberg, et al//Journal of Allergy and Clinical Immunology. – 2017. – V. 140, № 3. - P. 836-844. 120. GINA. Global Strategy for Asthma Management and Prevention. Update 2008: веб – сайт. URL: https://ginasthma.org/wpcontent/ uploads/2019/01/2008-GINA.pdf (дата обращения 03.15.2019). 8. GINA. Global Strategy for Asthma Management and Prevention. Update 2018: веб – сайт. 139 GINA https://ginasthma.org/wpcontent/ uploads/2018/04/2018 9. Granell, R. Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort / R. Granell, A. J. Henderson, J. A. Sterne//Allergy and Clinical Immunology. – 2016. – V.138, № 4. – Р. 1060- 1070. 10. Granell, R. Distinguishing Wheezing Phenotypes from Infancy to Adolescence: A Pooled Analysis of Five Birth Cohorts / R. Granell, S. Haider, S. Fontanella, A. Simpson, S. Turner, G. Devereux, S. H. Arshad, C. S. Murray, G. Roberts, J. W. Holloway//Ann Am Thorac Soc. – 2019. doi: 10.1513 / AnnalsATS.201811-837OC. 11. Grigg, J. Key paediatric messages from Amsterdam / J. Grigg, J. Barben, K. Bohlin, M. L. Everard, G. Hall, M. Pijnenburg, K. N. Priftis, F. Rusconi, F. Midulla//European Respiratory Journal. Open Res. – 2016. – V. 2. – Р. 00020. doi: 10.1183/23120541.00020-2016. 12. Grigg, J. Key paediatric messages from the 2017 European Respiratory Society International Congress / J. Grigg, J. Barben, M. L. Everard, et al//European Respiratory Journal. Open Res. – 2018. – V. 4. – P.00165. 13. Grigg, J. Matched cohort study of therapeutic strategies to prevent preschool wheezing/asthma attacks / J. Grigg, A. Nibber, J. Y. Paton, A. Chisholm, T. W. Guilbert, A. Kaplan, S. Turner, N. Roche, E. V. Hillyer, D. B. Price//Asthma and Allergy. – 2018. – V.11. – Р. 309–321. doi: 10.2147/JAA.S178531 14. Guilbert, T. W. Childhood asthma-predictive phenotype / T. W. Guilbert, D. T. Mauger, R. F. Lemanske//Allergy Clin Immunol Pract. – 2014. – V. 2, № 6. – Р. 664 - 670. doi: 10.1016/j.jaip.2014.09.010. 15. Guo, X. Epidemiology of childhood asthma in mainland China (1988–2014): A meta-analysis//X. Guo, Z. Li, W. Ling, J. Long, C. Su, J. Li, S. Liang, Li Suh // Allergy Asthma Proc. – 2018. – V. 39, №. 3. – Р. 15–29. doi: 10.2500,aap.2018.39.4131 16. Hallit, S. Wheezing phenotypes and risk factors in early life: The ELFE cohort / S. Hallit, B. Leynaert, M. C. Delmas, S. Rocchi, J. De Blic, C. Marguet, E. Scherer, M. N. Dufourg, C. Bois, G. Reboux, L. Millon, M. A. Charles, C. Raherison//PLoS One. – 2018. – V. 13, № 4. – Р. 0196711: веб – сайт. URL: https://doi.org/10.1371/journal.pone.0196711 (дата обращения 20.12.2018). 17. Henderson, A. J. Childhood asthma phenotypes in the twenty-first century / A. J. Henderson//Breathe. – 2014. – V. 10. – Р. 100-108. doi: 10.1183, 20734735. 014613. 18. Henderson, J. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in midchildhood / J Henderson, R. Granell, J. Heron, A Sherriff, A Simpson, A. Woodcock, D. P. Strachan, S. O. Shaheen, J. A. C. Sterne//Thorax. – 2008. – V. 63, № 11. – Р. 974-80. 19. Hirani, D. Loss of IL-6 enables lung growth in newborn mice exposed to prolonged hyperoxia / D. Hirani, K. Dinger, J. Mohr, C. Vohlen, B. Darvishan, F. Klein, E. L. Garcia, M. Odenthal, J. Dötsch, M. A. Alejandre Alcazar//European Respiratory Journal. – 2018. – V.52, Suppl. 62. – P. 1381-1382. doi: 10.1183/13993003.congress-2018.PA1381 20. Hodgekiss, C. Childhood phenotypic origins and characterisation of wheezing at 18-years / C. Hodgekiss, S. H. Arshad, G. Roberts, M. Larsson, R. Kurukulaaratchy//European Respiratory Journal. – 2016. – V. 48. – P. 329. doi: 10.1183/13993003.congress-2016.PA329 21. Holt, P. G. The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage/ P. G. Holt//Allergy and Clinical Immunology. – 2015. – V. 136, № 1. – P.15-22. 22. Huang, Y. J. The Microbiome in Asthma / Y. J. Huang, H. A. Boushey//Allergy Clin Immunol. – 2015. – V. 135, № 1. – Р. 25–30. doi: 10.1016/ j.jaci.2014.11.011. 23. Ilmarinen, P. Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma / P. Ilmarinen, L. E. Tuomisto, H. Kankaanranta//Mediators Inflamm. – 2015. - Р.514868. doi: 10.1155/2015/514868