Reproduktiv salomatlik va uro-nefrologik tadqiqotlar jurnali 2026 №2

Maqola mavzusi

THE ROLE OF AUTOIMMUNE THYROID DISEASES IN THE DEVELOPMENT OF FEMALE INFERTILITY AND TREATMENT TACTICS (95-98)

Mualliflar

Muratova Dilafruz Iskandar qizi,

Muassasa

Samarkand State Medical University

Annotatsiya

Among the root causes of infertility, autoimmune thyroid diseases are considered to be one of the most common endocrinological reasons for infertility in women, as they affect around 5-20% of the female population in the reproductive period all over the world. The review suggests that women with subclinical hypothyroidism and circulating anti-thyroid peroxidase antibodies may have very limited reproductive capacity due to several factors such as poor ovarian reserve, low-quality endometrium, and high miscarriage rates. Additionally, the combination of treatment with levothyroxine as well as immunotherapy has been found to result in a significant fertility increase and a better chance of carrying the pregnancy to term.

Kalit so'zlar

autoimmune thyroid disease, female infertility, anti-thyroid antibodies, ovarian reserve, assisted reproductive technology, levothyroxine therapy, reproductive endocrinology, pregnancy outcomes.

Adabiyotlar

1. Pires, M. I. Autoimmune thyroid disease in infertility and assisted reproductive technology: a review // PMC — PubMed Central. — 2025. — PubMed. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC12637338/ 2. Arlıer, S. Autoimmune Thyroid Disease and Female Fertility: Does Anti-TPO Accelerate Ovarian Aging? // J. Clin. Med. — 2025. URL: https://www.mdpi.com/2077-0383/14/22/8024 3. Concepción-Zavaleta, M. J. et al. Thyroid dysfunction and female infertility: A comprehensive review // ScienceDirect. — 2023. URL: https://www.sciencedirect.com/science/article/abs/pii/S1871402123001728 4. Bucci, I. et al. Thyroid Autoimmunity in Female Infertility and Assisted Reproductive Technologies // Front. Endocrinol. — 2022. URL: https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.768363/full 5. Potiris, A. Thyroid disorders: impact on female fertility and assisted reproduction outcomes // Hum. Reprod. J. — 2024. URL: https://hjog.org/wp-content/pdf/2024/23_1_03_Potiris.pdf 6. Перминова, С. Г. Бесплодие у женщин с заболеваниями щитовидной железы: принципы диагностики, тактика ведения // CyberLeninka. — 2013. URL: https://cyberleninka.ru/article/n/besplodie-u-zhenschin-s-zabolevaniyami-schitovidnoy-zhelezy-printsipydiagnostiki-taktika-vedeniya 7. Российская эндокринология: Аутоиммунные заболевания щитовидной железы и бесплодие // Пробл. эндокринол. — Фадеев В. В. URL: https://www.probl-endojournals.ru/jour/article/view/11531 8. Омариан, О. Р. Овариальный резерв и аутоиммунные заболевания у женщин с бесплодием // AIG-Journal.ru. URL: https://aigjournal.ru/articles/Osobennosti-ovarialnogo-rezerva-u-jenshin-s-besplodiem-i-autoimmunnym-tireoditom.html 9. Artyomenko, V. V. Thyroid autoimmunity and assisted reproductive technologies // Reproduct-Endo.com — 2025. URL: https://reproduct-endo.com/article/view/335472 10. Anvarova, S. A. Инновационные методы решения проблемы женского бесплодия при эндокринных нарушениях // Gynecology.su. — 2024. URL: https://www.gynecology.su/jour/article/view/2135?locale=ru_RU 11. Sarantaki, A., Tsiorou, K., Gourounti, K. The impact of Hashimoto's disease on female fertility: a systematic review // Int. J. Reprod. Contracept. Obstet. Gynecol. DOI: https://doi.org/10.18203/2320-1770.ijrcog20220192 12. Mehnaz, K., Akpak, Y. Thyroid disorders and fertility // Int. J. Res. Med. Sci. DOI: https://doi.org/10.18203/2320-6012.ijrms20150135