Reproduktiv salomatlik va uro-nefrologik tadqiqotlar jurnali 2026 №2

Maqola mavzusi

TUXUMDONLARI MUDDATIDAN OLDIN SO‘NGAN AYOLLARDA REPRODUKTIV FAOLIYATINI TIKLASH USULLARINI TAKOMILLASHTIRISH (ADABIYOTLAR TAHLILI) (19-23)

Mualliflar

Suleymanova Madina Shukhratovna, Negmadjanov Baxodur Boltayevich

Muassasa

Samarqand davlat tibbiyot universiteti

Annotatsiya

Kirish. So‘nggi yillarda tuxumdonlarning fiziologik va patologik funksiyalari haqidagi tushunchalarimiz sezilarli darajada kengaydi. Tuxumdonlar qarishining evolyutsion xususiyatlari ayol organizmidagi boshqa a’zolar va to‘qimalarning funksiyasi susayish mexanizmlaridan farq qilishi haqida ishonchli dalillar paydo bo‘ldi. Aniqlanishicha, umumiy ovarial rezervning shakllanishi hamda uning individual o‘zgaruvchanligi follikulogenez jarayoniga va menopauza boshlanish yoshiga sezilarli ta’sir ko‘rsatadi

Kalit so'zlar

ovarial rezerv, follikulogenez, yosh, tuxumdon

Adabiyotlar

1. Марченко Л.А., Машаева Р.И., Чернуха Г.Е. Современные воззрения наранние этапы фолликулогенеза и механизмы ормирования преждевременной недостаточности яичников // Гинекология.-2020.-№5. 2. Wang X., Wang L., Xiang W. Mechanisms of ovarian aging in women: a review // J. Ovarian Res. – 2023. - Vol. 16 (1). – P. 67. 3. Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients / T. Zhang, M. He, J. Zhang [et al.] // Front Physiol. – 2023. - Vol. 14. 4. França M.M., Mendonca B.B. Genetics of ovarian insufficiency and defects offolliculogenesis//Best Pract. Res. Clin. Endocrinol. Metab. – 2022. –Vol. 36 (1). 5. Di-Battista A., Moysés-Oliveira M., Melaragno M.I. Genetics of premature ovarian insufficiency and the association with X-autosome translocations// Reproduction. – 2020. - Vol. 160 (4). – P. R55-R64. 6. Park S.U., Walsh L., Berkowitz K.M. Mechanisms of ovarian aging // Reproduction. – 2021. - Vol. 162 (2). –P. R19-R33. 7. Targeted Next-Generation Sequencing Indicates a Frequent Oligogenic Involvement in Primary Ovarian Insufficiency Onset // Front Endocrinol. 2021. – Vol. 12. 8. Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing / J. Liu, L. Wang, Z. Wang [et al.] // Cells. – 2019. - Vol. 8(1). – P. 54. 9. Shay J.W., Wright W.E. Telomeres and telomerase: three decades of progress // Nat. Rev. Genet. – 2019. - Vol. 20 (5). – P. 299-309. 10. Zimmermann S., Martens U.M. Telomeres, senescence, and hematopoietic stem cells // Cell Tissue Res. – 2008. – Vol. 331, № 1. – P. 79-90. 11. Lin J., Epel E. Stress and telomere shortening: Insights from cellular mechanisms // Ageing Res. Rev. – 2022. – Vol. 73. 12. Billard P., Poncet D.A. Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing // Int. J. Mol. Sci. – 2019. - Vol. 20 (19). – P. 49-59. 13. Oxidative Stress and Human Ovarian Response-From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review / V. Immediata, C. Ronchetti, D. Spadaro // Antioxidants (Basel). – 2022. - Vol. 11 (7). – P. 1335. 14. Searching for female reproductive aging and longevity biomarkers / S. Yureneva, V. Averkova, D. Silachev //Aging. – 2021. - Vol. 13 (12). – P. 16873-16894. 15. A syndrome characterized by primary ovarian insufficiency and decreased stature / F. Albright [et al.] // Am. J. Med. Sci. – 1942. 16. Huhtaniemi I., Alevizaki M. Gonadotrophin resistance // Best Pract. Res. Clin. Endocrinol. Metab. – 2006. - Vol. 20. – P. 561–576. 17. Аменорея и олигоменорея:Клинические рекомендации. - М., 2021. 18. Nelson H.D. Menopause // Lancet. – 2008. - Vol. 371 (9614). – P. 760- 19. Premature ovarian insufficiency: an International Menopause Society White Paper / N. Panay, R.A. Anderson, R.E. Nappi // Climacteric. – 2020. - Vol. 23 (5). – P. 426-446. 20. Premature menopause in a multi-ethnic population study of the menopause transition / J.L. Luborsky, P. Meyer, M.F. Sowers // Hum. Reprod. – 2003. - Vol. 18 (1). – P. 199–206.