Kardiorespirator tadqiqotlar jurnali. Maxsus son. 2022


Maqola mavzusi

STUDY OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC HEART FAILURE (192-199)

Mualliflar

Shoalimova Z.M.

Muassasa

Tashkent Medical Academy

Annotatsiya

One of the factors defining prognosis in patients with heart failure (CHF) is endothelial dysfunction. The aim of the given study was to define antithrombogenic and vasolidating vascular wall activity in patients with CHF. 60 examined patients comprised two groups: the main group consisted of 40 patients after Qmyocardial infarction, the comparison group consisted of 20 patients. To determine antithrombogenic properties of vascular wall, «cuff testing» method developed by V.P.Balouda was used. Endothelial vasomotor function was studied using probes with reactive hyperemia and nitroglycerin. In patients with CHF decrease of antithrombogenic and vasolidating vascular wall activity was observed. During six months of monitoring the number of repeated unfavorable cardiovascular events in patients with IV functional class CHF having long term CHF symptoms and EF value < 33% is reliably higher in comparison with patients of I, II and III functional classes of CHF.

Kalit so'zlar

chronic heart failure, endothelial dysfunction.

Adabiyotlar

1. Arbolishvili, G.N. Relationship between various indicators of heart rate variability and the mechanism of death in patients with chronic heart failure and left ventricular systolic dysfunction / G.N. Arbolishvili, V.Yu. Mareev, Yu.N. Belenkov // Heart failure.—2006.—No. 4(38).—S.172—178. 2. Solomon, SD Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients / SD Solomon, N. Anavecar, H. Skali [et al.] // Circulation.— 2005.—No. 112(24). —P.3738-3744. 3. 3. Mareev, V.Yu. Comparative characteristics of patients with CHF depending on the values of the ejection fraction according to the results of the Russian multicenter study EPOCHA-O-CHF: again about the problem of CHF with preserved systolic function of the left ventricle / V.Yu. Mareev, M.O. Danielyan, Yu.N. 3. Belenkov // Heart failure.—2006.—No. 112(38).— P.164—171. 4. Olbinskaya, L.I. Endothelial dysfunction in patients with coronary heart disease complicated by chronic heart failure, and the possibility of correction with isosorbide-5-mononitrate / L.I. Olbinskaya, Zh.M. Sizova, A.V. Ushakova // Cardiology.—2001.— No. 3.—S.29—32. 5. Peripheral vascular remodeling as a mechanism of exercise limitation in patients with chronic heart failure / Yu [et al.] // Eur. Heart. J.—1998.—No. 19.—P.65. 6. Vizir, V.A. Prospects for reversal of endothelial dysfunction in patients with congestive heart failure / V.A. Vizir, A.E. Berezin // Clinical Medicine. - 2000. - No. 7. - P. 36-39. 7. Baluda, V.P. The value of determining the antithrombogenic properties of the vessel wall in the prevention of thrombosis / V.P. Baluda, I.I. Deyanov // Cardiology.—1988.— No. 5.—S. 8. Lieberman, EH Lieberman, MD Gerhard, A. Uehata [et al.] // Am. J. Cardiol.—1996.—No. 78.—P.22— 27.9. Zateishchikova A.A. Endothelial regulation of vascular tone: research methods and clinical significance / A.A. Zateishchikova, D.A. Zateyshchikov // Cardiology. - 1998. - No. 9. - P. 69-80. 10. Cioffi, G. Systemic thromboembolism in chronic heart failure. A prospective study in 406 patients / G. Cioffi // Eur. Heart. J.—1996.—No. 17.—P.1381—1389. 11. Vanhoutte, PM Endothelial dysfunction and atherosclerosis / PM Vanhoutte // Eur. Heart. J.—1997.—No. 18.—P.19—29.