Биология ва тиббиёт муаммолари 2026, №3 (169)
Maqola mavzusi
COMPREHENSIVE OPTIMIZATION OF SURGICAL TREATMENT FOR TOXIC GOITER BASED ON IMMUNOLOGICAL RISK STRATIFICATION AND PREOPERATIVE PLASMAPHERESIS (95-100)
Mualliflar
Daminov Abdurasul Takhirovich
Muassasa
Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Annotatsiya
The article presents an expanded scientific analysis of the diagnosis and surgical treatment of toxic forms of goiter. The study is based on the clinical material of 498 patients with toxic goiter who underwent examination and surgi-cal treatment from 2005 to 2024 at the surgical departments of the Samarkand State Medical University clinic and City Clinical Hospital No. 1. Diffuse toxic goiter was diagnosed in 204 patients, mixed toxic goiter in 159 patients, nodular toxic goiter in 114 patients, and recurrent postoperative toxic goiter in 21 patients. The article substanti-ates the importance of differentiated selection of the operative volume based on the level of antibodies to thyroid-stimulating hormone receptors. Particular attention is paid to the role of plasmapheresis in preoperative prepara-tion of patients with severe thyrotoxicosis, intolerance or resistance to antithyroid therapy. The proposed compre-hensive approach made it possible to reduce the risk of postoperative thyrotoxic crisis, minimize recurrence after subtotal thyroid resection, and improve long-term clinical outcomes. The obtained data confirm that immunological risk stratification, precise thyroid surgery, and individualized preoperative preparation are key components of safe and effective endocrine surgery in patients with toxic goiter.
Kalit so'zlar
toxic goiter, diffuse toxic goiter, thyrotoxicosis, thyroidectomy, subtotal thyroid resection, antibodies to TSH recep-tors, plasmapheresis, Graves’ disease, endocrine surgery.
Adabiyotlar
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