Журнал кардиореспираторных исследований 2026. №2/3

Maqola mavzusi

Komplement tizimi faolligining tizimli qizil yugurik shakllanishidagi o‘rni (56-59)

Mualliflar

B.U. Nizomov, K.A. Islamova

Muassasa

Samarqand davlat tibbiyot universiteti

Annotatsiya

Tizimli qizil yugurik (TQY) — genetik, immunologik va tashqi omillar ta’sirida rivojlanuvchi, ko‘p tizimli autoimmun kasallik bo‘lib, uning asosini autoantitanalar hosil bo‘lishi, immun komplekslarning to‘qimalarda to‘planishi va surunkali yallig‘lanish jarayonlari tashkil etadi. Ushbu jarayonlar kechishida komplement tizimi muhim patogenetik bo‘g‘in bo‘lib ishtirok etadi. Mazkur tadqiqotda komplement tizimining klassik, alternativ va lektinli faollashuv yo‘llarining o‘ziga xos xususiyatlari, shuningdek, C3 va C4 komponentlari darajasidagi o‘zgarishlarning klinik-laborator ahamiyati keng yoritilgan. Komplement tizimi faollashuvining ortishi sababli immun yallig‘lanish reaksiyalari kuchayib, natijada organ va to‘qimalar zararlanishining ortishiga olib kelishi ilmiy manbalar asosida tahlil qilingan. Shu bilan birga, TQY bilan kasallangan bemorlarda komponentlar darajasini baholashning diagnostik qiymati, kasallik faolligini aniqlash va prognozni belgilashdagi ahamiyati ham ko‘rib chiqilgan. Zamonaviy adabiyotlar tahlili komplement tizimi va TQY patogenezi o‘rtasidagi mustahkam o‘zaro bog‘liqlikni tasdiqlaydi hamda bu tizimni terapevtik nishon sifatida o‘rganish istiqbolli yo‘nalish ekanligini ko‘rsatadi.

Kalit so'zlar

tizimli qizil yugurik, komplement tizimi, autoantitana oqsillari, C3, C4, immunopatogenez.

Adabiyotlar

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