Биология ва тиббиёт муаммолари 2025 №6 (166)

Maqola mavzusi

CT-BASED DETECTION OF MYOSTEATOSIS IN PATIENTS WITH SARCOPENIA ASSOCIATED WITH ONCOLOGICAL DISEASES (275-278)

Mualliflar

Shakhanova Shakhnoza Shavkatovna, Rakhimov Nodir Makhammatkulovich, Sharipov Obid Uralovich, Kamalova Barno Zafarovna

Muassasa

1 - Samarkand State Medical University, Republic of Uzbekistan, Samarkand; 2 - Samarkand Regional Interdistrict Hospice, Republic of Uzbekistan, Samarkand; 3 - Samarkand Branch of the Republican Specialized Scientific and Practical Center of Oncology and Radiology, Republic of Uzbekistan, Samarkand

Annotatsiya

The study included 102 oncological patients who underwent computed tomography (CT) with body composition assessment at the L3 vertebral level. Sarcopenia was detected in 56.8% of patients, myosteatosis in 48.0%, and their combination in 36.2%. Patients with sarcopenia showed a significant reduction in skeletal muscle density (SMD 36.9 ± 6.2 HU vs. 42.7 ± 5.8 HU; p < 0.001). Myosteatosis correlated with elevated IL-6 and CRP levels and was associated with increased chemotherapy toxicity and reduced one-year survival (68.9% vs. 84.6%). CT-based assessment of myosteatosis is an effective diagnostic and prognostic tool in oncological patients with sarcopenia.

Kalit so'zlar

sarcopenia, myosteatosis, computed tomography, cancer, skeletal muscle density, IL-6, inflammation, prognosis.

Adabiyotlar

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