Журнал кардиореспираторных исследований 2026. №3

Maqola mavzusi

Bronxial astma bilan og‘rigan bemorlarda tizimli yallig‘lanish va oksidlanish stressining ko‘rsatkichlari (53-56)

Mualliflar

Iskandarova F.I., Juraev Sh.B.

Muassasa

Samarqand davlat tibbiyot universiteti

Annotatsiya

Tadqiqotning maqsadi BA bilan og‘rigan bemorlarda tizimli yallig‘lanish va oksidlanish stressi markerlari darajasini baholash va ularning tana vazni indeksi (TVI) bilan o‘zaro bog‘liqligini o‘rganishdan iborat. Materialы i metodы. BA bilan kasallangan 36 nafar bemor tekshirildi. IL-6, IL8, TNF-α darajasi, shuningdek oksidlovchi stress ko‘rsatkichlari (S O‘MB, RAP O‘MB) aniqlandi. TVI ga qarab qiyosiy va korrelyatsion tahlil o‘tkazildi. Natijalar. TVIning oshishi IL-6, IL-8, TNF-α va S O‘MB darajasining sezilarli darajada oshishi bilan bog‘liqligi aniqlandi (r<0,05). TVI va IL-6 (r=0,802), TNF-α (r=0,746) o‘rtasida kuchli to‘g‘ridan to‘g‘ri korrelyatsion bog‘liqlik, shuningdek IL-8 (r=0,651) bilan o‘rtacha kuchli bog‘liqlik aniqlandi. TVI va RAP O‘MB o‘rtasida teskari korrelyatsion bog‘liqlik aniqlandi (r=-0,333). Xulosa. BA bilan og‘rigan bemorlarda TVIning oshishi tizimli yallig‘lanish va oksidlanish stressining kuchayishi bilan birga kechadi, buni ushbu kasallikni olib borishda hisobga olish lozim.

Kalit so'zlar

bronxial astma, tizimli yallig‘lanish, oksidlanish stressi, IL-6, IL-8, TNF-α, tana vazni indeksi

Adabiyotlar

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