Gepato-gastroenterologik tadqiqotlar jurnali 2026 №1

Maqola mavzusi

IMMUN TROMBOTSITOPENIYANING ETILIOLOGIK OMILLARI VA KLINIK KO‘RINISHLARINING TAHLILI (48-51)

Mualliflar

Mamatkulova Feruza Xaydarovna

Muassasa

Samarkand State Medical University

Annotatsiya

ANNOTATSIYA Immun trombotsitopeniya (ITP) odatda anemiya yoki leykopeniya bilan bog‘liq bo‘lmagan qon ketishi bilan kechadigan kasallikdir. Odatda kattalarda surunkali, lekin bolalarda ko‘pincha o‘tkir va o‘tib ketuvchi turlari bo‘ladi. Tashxis odatda trombotsitopeniyaning boshqa sabablarini (masalan, OVI infeksiyasi, gepatitlar) inkor etish asosida klinik qo‘yiladi. Davolash kortikosteroidlar, splenektomiya, immunosupressantlar, trombopoetin retseptorlari agonistlari yoki taloq tirozin kinaza ingibitori fostamatinibni o‘z ichiga oladi. Hayot uchun xavfli qon ketish holatida trombotsitar massa quyish, vena ichiga kortikosteroidlar, vena ichiga anti-D immunoglobulin yoki vena ichiga immunoglobulin alohida yoki birgalikda yuborilishi kerak. Immun trombotsitopeniya (ITP) - bu hayot uchun xavfli qon ketishini o‘z ichiga olgan og‘ir gemorragik sindromlar bilan tavsiflanadigan kasallik bo‘lib, etiotrop terapiyani qo‘llash orqali, immunosupressantlarga qarshilikni yengib o‘tib va barqaror remissiyaga erishishi mumkin. Bu antitrombotsit antitelolarining rivojlanishiga turli omillarning ta’sirini o‘rganishni talab qiladi.

Kalit so'zlar

Kalit so‘zlar: Immun trombotsitopeniya, o‘tkir, surunkali, gemorragik sindrom, kortikosteroidlar, splenektomiya.

Adabiyotlar

Список литературы/ Iqtiboslar / References 1. Kovaleva L.G., PustovaaYE.I., SafonovaT.I. Idiopaticheskaya trombotsitopenicheskaa purpura (ITP) vzroslix. Pervichnaa trombotsi- topenia (ITP) vzroslix. Bolezn Berlgofa. M.: Hyu Mun; 2014 2. Kovaleva L.G., Safonova T.I., Pustovaa YE.I., Kolosova YE.H., Radnenko A.A. Kliniko-stati- sticheskiye danniye i otsenka razlichnix metodov terapii idiopaticheskoy trombotsitopeniche- skoy purpuri. Terapevticheskiy arxiv. 2011; 4:60-5. 3. Lisukov I.A., Maschan A.A., Shamardina A.B., Chagorova T.B., Davidkin I.L., Sicheva T.M. i dr. Immunnaa trombotsitopenia: klinicheskiye proavlenia i otvet na terapiyu. Promemutoch- niy analiz dannix Rossiyskogo registra patsi- yentov pervichnoy immunnoy trobotsitopeniyey i obzor literaturi. Onkogematologia. 2013; 2: 61--9. 4. Maschan A.A., Rumansev A.G., Kovaleva L.G., Afanasyev B.B., Pospelova T.I., Zaritskiy A.Y. i dr. Rekomendatsii Rossiyskogo soveta eks- pertov po diagnostike i lecheniyu bolnix pervichnoy immunnoy trobotsitopeniyey. Onkogema- tologia. 2010; 3: 36-45. 5. Reshetnak T.M. Antifosfolipidniy sindrom: diagnostika i klinicheskiye proavlenia (leksia) 2014. Hauchno-prakticheskaa doi:10.14412/1995-4484-2014-56-71. 6. Cines D.B., Cuker A., Semple J.W. Pathogen- esis of immune thrombocytopenia. Presse Med. 2014; 43(4, Pt2): e49--59. doi: 10.1016/j.lpm.2014 .01.010 7. Fogarty P. Chronic ITP in adults: epidemi- ology and clinical presentation. Hematol. Oncol. Clin. North. Am. 2009; 23(6): 1213--21. doi: 10.1016/ j.hoc.2009.08.004. 8. Neunert C., Lim W., Crowther M., Cohen A., Solberg L.Jr., Crowther M.A. The American Society of Hematology 2011 evidence-based practice guideline thrombocytopenia. Blood. 2011; 117(16): 4190-207. doi: 10.1182/blood-2010-08-302984. Thota S., Kistangari G., Daw H., Spiro T. Im- mune thrombocytopenia in adults: an update. Cleve. Clin. J. Med. 2012; 79(9): 641-50. doi: 10.3949/ ccjm.79a.11027. 10. Makhmonov L. S., Mamatkulova F. Kh., Kholturaeva D. F., Muyiddinov Z. Z. IMPORTANCE OF DETECTION OF HEPSIDINE AND INTERLEUKINS IN "Science and Education" Scientific Journal / Impact Factor 3,848 (SJIF) February 2023 / Volume 4 Issue 2. 11. Mamatkulova F. X. Mamatova N. T. Ruziboeva.O. N. Prevention Of Anemia In Patients With Tuberculosis. The American Journal of Medical Sciences and Pharmaceutical Research, 2(11), 62–65. 12. FX Mamatkulova, SF Ziyodinov, DX Suyundiqov. Yurak-qon tomir kasalliklari bo ‘lgan bemorlarda qonining elektrokinetik va klinik-laborator ko ‘rsatmalari. Science and Education 5 (2), 154-160 13. F.X.Mamatkulova., X.I.Axmedov. Temir tanqisligi kamqonligining kelib chiqish sabablari va davolashga zamonaviy yondoshuv. “SCIENCE AND EDUCATION” VOLUME 4,ISSUE1.2023/195-203 14. Dadajonov, U., Abdiyev, K., Mamatkulova, F., & Dadajonov, U. (2021). Innovatsionniye metodi lecheniya immunnoy trombotsitopenicheskoy purpuri u lits molodogo vozrasta. Obshestvo i innovatsii, 2(4/S), 52-56. 15. Mamatkulova F. X. Mamatova N. T. Ruziboeva.O. N. Prevention Of Anemia In Patients With Tuberculosis. The American Journal of Medical Sciences and Pharmaceutical Research, 2(11), 62–65. 16. L.S.Makhmonov., F.Kh.Mamatkulova., M.B. Berdiyarova, K.E. Shomurodov.THE MAIN CAUSES OF ANEMIA IN IRON AND VITAMIN B 12 DEFICIENCY ASSOCIATED WITH HELICOBACTER PYLORI 17. Makhmonov L. S., Mamatkulova F. Kh., Kholturaeva D. F., Muyiddinov Z. Z. IMPORTANCE OF DETECTION OF HEPSIDINE AND INTERLEUKINS IN "Science and Education" Scientific Journal / Impact Factor 3,848 (SJIF) February 2023 / Volume 4 Issue 2. 18. Maxmonov, Lutfulla Saydullayevich, Feruza Xaydarovna Mamatqulova, and Zafar Mardonovich Umarov. "Ginekologik amaliyotda temir tanqisligi anemiyalari va davolashga zamonaviy yondoshuvlar." Science and Education 5.2 (2024): 635-647. 19. Maxmonov, L. S., Mamatqulova, F. X., & Meliqulov, B. S. (2023). Trombotsitopatiya bilan kasallangan ayollarda tuxumdon apopleksiyasi kechishi va asoratini davolash tamoyillariga zamonaviy yondashuv. Science and Education, 4(2), 384-391. 20. Makhmonov L. S., Mamatkulova F. Kh., Kholturaeva D. F., Muyiddinov Z. Z. IMPORTANCE OF DETECTION OF HEPSIDINE AND INTERLEUKINS IN IRON DEFICIENCY ANEMIA. Asian Journal of Multidimensional Research ISSN: 2278-4853 Vol. 11, Issue 4, April 2022 21. Dadajanov U. D., Mamatkulova Feruza Xaydarovna, R. Oyjamol N. Features Of Thrombophilia In Covid-19 European Journal of Molecular & Clinical Medicine2020/12/26. 07/03 22. Mamatkulova Feruza Khaydarovna, Akhmedov Husan Isrofilovich, Abdiev Kattabek Makhmatovich. Essential Thrombocythemia - Principal Analysis in Children and Adolescents. JOURNAL OF INTELLECTUAL PROPERTY AND HUMAN RIGHTS Volume: 2 Issue: 10 | Oct – 2023 ISSN: 2720-6882. 23-29. 23. ON Ruziboeva, KM Abdiev, AG Madasheva, FK Mamatkulova MODERN METHODS OF TREATMENT OF HEMOSTASIS DISORDERS IN PATIENTS WITH RHEUMATOID ARTHRITIS Ученый XXI века 78 (7), 8-11. 24. LS Maxmonov, FX Mamatkulova, OE Alimov, UU Raxmonov. Yelka Kamari Operatsiyalarida Regional Anesteziyaning Samaradorligi Miasto Przyszłości 47, 993-997 25. Abdiyev K.M., Dadajanov U.D., Mamatkulova F.X. Nekotoriye aspekti vedeniya bolnix s trombotsitopenicheskoy purpuroy oslojnennoy s apopleksiyey yaichnika. Problemi ekologii, zdorovya, farmatsii i parazitologii. Nauchniye trudi. Moskva. 2013 g. Str. 372-373. 26. Makhmonov L.S., Sh. Koraboev S.K., Gapparova N..Sh, Mamatkulova F. Kh. Early diagnosis and treatment of funicular myelosis in v12 deficiency anemia. Asian Journal of Multidimensional Research Year : 2022, Volume : 11, Issue : 5.First page : ( 369) Last page : ( 373)Online ISSN : 2278-4853. 27. Mamatkulova F.X., Alimov O.E., Namozov M.N.O‘. Abdominal jarroxlik operatsiyalardan keyingi davrda regional anesteziyaning samaradorligi va rivojlangan kamqonlikni davolash //Science and Education. – 2023. – T. 4. – №. 2. – С. 445-452. 28. KM Abdiev, AG Madasheva, FK Mamatkulova MODERN METHODS OF TREATMENT OF HEMORRHAGIC SYNDROME AT AN EARLY STAGE IN PATIENTS WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA. УЧЕНЫЙ XXI ВЕКА, 41-44 29. MF Khaydarovna, AH Isrofilovich, AK Makhmatovich Essential Thrombocythemia-Principal Analysis in Children and Adolescents. Journal of Intellectual Property and Human Rights 2 (10), 23-29 30. Gadayev A.G., Maxmonov L.S., Mamatqulova F.X. Helicobacter pylori bilan assotsiyalangan temir va vitamin B12 tanqisligi kamqonliklarida yallig‘lanish sitokinlarining ayrim laborator ko‘rsatkichlar bilan o‘zaro bog‘liqligi. – 2022.