Журнал кардиореспираторных исследований 2025. №1

Maqola mavzusi

SURUNKALI YURAK YETISHMOVCHILIGIDA RIVOJLANADIGAN ANEMIYALAR (67-72)

Mualliflar

Mamatkulova F.X.

Muassasa

Samarqand Davlat Tibbiyot Universiteti

Annotatsiya

So‘nggi o‘n yilliklarda surunkali yurak yetishmovchiligi (SYUYE) bo‘lgan bemorlarning umr ko‘rish davomiyligi sezilarli darajada oshdi. Shu munosabat bilan, kardiologlar va terapevtlar anemiya va yurak patologiyasi kabi ko‘plab birga keladigan kasalliklari bo‘lgan bemorlarni olib borishda bir qator yangi savollarga duch kelishmoqda. Anemiya SYUYE ning og'irligini kuchaytiradi, asosiy dorilarning samaradorligini pasaytiradi, prognozni yomonlashtiradi, kasalxonaga yotqizish chastotasini oshiradi va bemorlarning o'limini oshiradi [8]. Anemiya bilan og'rigan bemorlarda anemiya fonida yurak mushaklari faoliyatining pasayishi kuzatiladi va miyokard ishemiyasining rivojlanishi kuchayadi. Ko'pchilik anemiyaning SYUYEga salbiy ta'sirining etakchi rolini temir tanqisligi (TT) bilan bog'laydi. Dispepsiya fonida energiya almashinuvi pasayadi, mitoxondriyal disfunktsiya rivojlanadi va gem o'z ichiga olgan miyoglobin oqsilini ishlab chiqarish buziladi, bu esa miyokard funktsiyasining pasayishiga olib keladi. Anemiya, TT va SYUYE, chap qorincha gipertrofiyasi va kengayishi, skelet mushaklari va miyokard funktsiyasining pasayishi o'rtasidagi bog'liqlik ko'rsatilgan, normal temir darajasi esa chidamlilik va aerobik imkoniyatlarning oshishi bilan bog'liq. Boshqa ma'lumotlarga ko'ra, anemiya mavjudligi yoki yo'qligi TT bilan bog'liq noqulay prognozga ta'sir qilmaydi. Surunkali yurak etishmovchiligi bo'lgan bemorlarda o'limning oshishi bilan bog'liq. Ushbu ma'lumotlar shuni ko'rsatadiki, TT ning mavjudligi anemiya mavjudligiga qaraganda kamroq qulay prognoz bilan bog'liq [12]. Bugungi kunda ma'lumki, TT bilan bog’liq holda rivojlanadigan anemiya SYUYE bilan og'rigan bemor uchun juda salbiy holat hisoblanadi. Donald Silverberg boshchiligidagi tadqiqotchilar guruhi SBEda "kardiorenal anemiya sindromi" (cardio renal anemia syndrome)ni o‘rganishdi va natijada, bu bemorlarni davolash taktikalarida ba’zi o‘zgarishlar kiritilishiga yordam beradigan tamoyillarni ishlab chiqishiga sabab bo‘ldi [4]. Shuningdek, yaqinda o‘tkazilgan bir nechta tadqiqotlar natijalari, bizga ushbu sharhda aks ettirilgan SBEda anemiya patogenezi va davolash bo‘yicha ma’lum xulosalarni qayta ko‘rib chiqishimizga turtki bo‘ldi.

Kalit so'zlar

Surunkali yurak yetishmovchiligi, surunkali kasalliklar kamqonligi, eritropoetin, temir tanqisligi anemiyasi, peroral va tomir ichiga temir preparatlari.

Adabiyotlar

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