Doktor axborotnomasi 2025, №4 (121)


Maqola mavzusi

THE ROLE OF TRIBULUS TERRESTRIS IN THE MANAGEMENT OF MALE SEXUAL DISORDERS (91-97)

Mualliflar

R. Gafarov, P. Shukla

Muassasa

Samarkand state medical university, Samarkand, Uzbekistan

Annotatsiya

This non-systematic literature review comprehensively summarises the phytotherapeutic potential of Tribulus terrestris in the management of erectile dysfunction (ED) and male sexual disorders. Review integrates evidence from pharmacological, experimental and clinical studies to elucidate the mechanisms of action, bioactive composition and therapeutic relevance of Tribulus terrestris in the context of ED and disorders of male sexuality.

Kalit so'zlar

Tribulus terrestris, erectile dysfunction, testosterone, steroidal saponins.

Adabiyotlar

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Epub 2013 Mar 15. PMID: 23526694; PMCID: PMC3604572. 5. Vladimir Neychev and Vanyo Mitev, Pro-sexual and Androgen Enhancing Effects of Tribulus terrestris L.: Fact or Fiction, Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2015.12.055 6. Tomowa MP, Panowa D, Wulfson NS. Steroidsaponine und Steroidsapogenine. IV. Saponine aus Tribulus ter restris [Steroid saponines and sapogenins. IV. Saponines from Tribulus terrestris (author's transl)]. Planta Med. 1974;25(3):231-237. doi:10.1055/s-0028-1097936 7. Zarkova, S. (1976). Morphological and histological changes in testes of rat under the effect of TB-68, Med. N, 4, 49-53. 8. Dinchev D, Janda B, Evstatieva L, Oleszek W, Aslani MR, Kostova I. Distribution of steroidal saponins in Tribu lus terrestris from different geographical regions. Phytochemistry. 2008 Jan;69(1):176-86. doi: 10.1016/ j.phytochem.2007.07.003. Epub 2007 Aug 23. PMID: 17719068. 9. 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GamalEl Din SF, Abdel Salam MA, Mohamed MS, Ahmed AR, Motawaa AT, Saadeldin OA, Elnabarway RR. Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in pa tients with late-onset hypogonadism: A placebo-controlled study. Urologia. 2019 May;86(2):74-78. doi: 10.1177/0391560318802160. Epub 2018 Sep 25. PMID: 30253697. 16. Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017 May;99:20-26. doi: 10.1016/j.maturitas.2017.01.011. Epub 2017 Feb 12. PMID: 28364864. 17. Roaiah MF, Elkhayat YI, Abd El Salam MA, Din SFG. Prospective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Parameters in Males with Unexplained Infertility. J Diet Suppl. 2017 Jan 2;14(1):25-31. doi: 10.1080/19390211.2016.1188193. Epub 2016 Jun 23. Erratum in: J Diet Suppl. 2018 Nov 2;15(6):1014. doi: 10.1080/19390211.2018.1459390. PMID: 27337519. 18. Santos HO, Cadegiani FA, Forbes SC. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review. Clin Ther. 2022 Aug;44(8):1129-1149. doi: 10.1016/ j.clinthera.2022.06.006. Epub 2022 Jul 7. PMID: 35810031. 19. Huff R, Karpinska-Leydier K, Maddineni G, Begosh-Mayne D. Rhabdomyolysis Risk: The Dangers of Tribulus Terrestris, an Over-the-Counter Supplement. Am J Case Rep. 2024 Jul 16;25:e943492. doi: 10.12659/ AJCR.943492. PMID: 39012853; PMCID: PMC11315611.