Doktor axborotnomasi 2025, №3 (120)

Тема статьи

INDICATORS USED TO ASSESS THE SUCCESS OF TREATMENT OF PSORIASIS WITH METHOTREXATE (10-13)

Авторы

M. M. Akhmedova

Учреждение

Samarkand state medical university, Samarkand, Uzbekistan

Аннотация

The purpose of current research was to study the effectiveness of methotrexate in the treatment of psoriasis. During the study, 36 patients aged 15 to 35 years were examined, divided into two groups: control and main. The con trol group included 18 patients (7 women and 11 men) with moderate psoriasis. The clinical picture was characterized by the presence of psoriatic plaques on the elbow and knee joints, as well as papules with scales on the scalp. Patients of this group received systemic therapy with methotrexate (Methotrexate Evebe 50 mg/5 ml) at a dose of 0.25 mg/kg of body weight. To prevent side effects, folic acid was prescribed to all patients in this group: 1 tablet three times a day throughout the study period. The main group consisted of 6 women and 12 men with moderate psoriasis. The clin ical picture was similar to the control group: psoriatic plaques were localized in the elbow and knee joints, and papules with scales were present in the hairy part of the head. Patients in this group also received systemic methotrexate thera py (Methotrexate Evebe 50 mg/5 ml), but the dosage was selected individually depending on age: 20 mg/5 ml for pa tients aged 15-20 years, 25 mg/5 ml for patients aged 21-25 years, and 30 mg/5 ml for patients aged 26-30 years. The study results showed that a more effective regimen for treating psoriasis is the use of methotrexate (Methotrexate Evebe 50 mg/5 ml) at a dose of 0.25 mg/kg of body weight with subsequent longer preservation of the remission peri od compared to the main group. In conclusion it should be said that this treatment regimen is recommended for the treatment of moderate and severe psoriasis.

Ключевые слова

psoriasis, methotrexate, treatment.

Литературы

1. Abdullaev X. D. et al. Use of local treatment with pimicralimus for the treatment of papulious dermatosis. - 2023. 2. Tillaqobilov I. B., Abdullaev X. D., qizi Subxonova Z. S. Evaluation of the effectiveness of monoclonal results in the treatment of psoriaz //Educational Research in Universal Sciences. - 2024. - Vol. 3. - No. 1 SPECIAL. - P. 310-313. 3. Tolibov M. M. et al. Sevoran use in the management of papulosquamous dermatoses //research and education. - 2023. - Vol. 2. - No. 6. - P. 112-119. 4. Toshev S. U., Abdullayev H. D., Mamatov J. M. Influence of complex therapy with the use of sulodexide on paper pressure in patients with psoria //Educational Research in Universal Sciences. - 2024. - Vol. 3. - No. 1. - P. 340 344. 5. Toshev S. U., Abdullayev H. D., Mamatov J. M. The role of glycozaminoglycans in the treatment of psoria (literature review) //Educational Research in Universal Sciences. - 2024. - Vol. 3. - No. 1. - P. 330-334. 6. Toshev S. U., Abdullayev H. D., Mamatov J. M. Influence of complex therapy with the use of sulodexide on the functional state of the liver of psoriasis patients //Educational Research in Universal Sciences. - 2024. - Vol. 3. - No. 1 SPECIAL. - P. 345-349. 7. Toshev S. U., Abdullayev H. D., Mamatov J. M. Mechanisms of damage to the microcirculatory turn and connec tive tissue structures in psoria //Educational Research in Universal Sciences. - 2024. - Vol. 3. - No. 1 SPECIAL. - P. 335-339. 8. Utaev A. Zh., Davlatovich Abdullaev Kh., Abdullaev D. M. Comparative efficiency of laser and phototherapy in the treatment of psoria //Modern Scientific Research International Scientific Journal. - 2024. - Vol. 2. - No. 1. - P. 127-132.