Биология ва тиббиёт муаммолари 2026, №5 (171)

Тема статьи

PLEOMORPHIC XANTHOASTROCYTOMA, CNS WHO GRADE 3, IN A FOUR-YEAR-OLD CHILD: RADIOLOGIC–PATHOLOGIC CORRELATION OF A RARE CORTICAL TUMOR (480-484)

Авторы

Djuraeva Nigora Mukhsumovna, Abdukhalimova Khanum Valentinovna, Kholmirzaev Murodjon Ali ugli, Abduvakhobova Komila Mirsaid kizi

Учреждение

Republican Specialized Scientific and Practical Medical Center of Surgery named after Academician V. Vakhidov, Republic of Uzbekistan, Tashkent

Аннотация

Aim: to describe the MRI features and radiologic–pathologic correlation of a rare paediatric cortical tumour, pleomorphic xanthoastrocytoma (PXA), using a clinical case. Materials and methods: a 4-year-old girl present-ing with headache, nausea, vomiting, dizziness and gait instability underwent 3.0 T MRI (DWI/ADC, SWI, con-trast-enhanced T1, diffusion tensor tractography), microsurgical resection, and histological and immunohisto-chemical examination. Results: MRI showed a 5.8×5.7×6.4 cm predominantly cystic cortico-subcortical mass in the lateral right frontoparietal region with a peripheral solid component, irregular peripheral enhancement, marked vasogenic oedema and mass effect. Subtotal resection was performed. The tumour was positive for GFAP, Olig2 and CD34 and negative for IDH1 and BRAF V600E, with a Ki-67 index of approximately 35%; PXA, CNS WHO grade 3 (ICD-O 9424/3), was diagnosed, and adjuvant radiotherapy was given. Conclusion: PXA should be included in the differential diagnosis of large superficial cystic cerebral masses in children; the final diagnosis requires interpretation of MRI findings together with histological and immunohistochemical data.

Ключевые слова

pleomorphic xanthoastrocytoma, multiparametric neuroimaging, cystic-solid mass, immunohistochemistry, radi-ologic–pathologic correlation.

Литературы

1. Boston Children's Hospital. Pleomorphic xan-thoastrocytoma [Electronic resource]. URL: https://www.childrenshospital.org/conditions-treatments/pleomorphic-xanthoastrocytoma (дата обращения: 18.10.2026). 2. Byun J., Hong S.H., Kim Y.H., Kim J.H., Kim C.J. Peritumoral edema affects the prognosis in adult pleomorphic xanthoastrocytoma: retrospective anal-ysis of 25 patients // World Neurosurgery. 2018. Vol. 114. P. e457–e467. DOI: 10.1016/j.wneu.2018.03.007. 3. Ferreira Furtado L.M., Da Costa Val Filho J.A., Rodrigues da Costa G.A., Braga P.S.G. Pleomorphic xanthoastrocytoma of the frontal lobe in a child: a rare entity // Cureus. 2021. Vol. 13, № 6. Art. e15566. DOI: 10.7759/cureus.15566. 4. Gaillard F., Rana A., Sharma R., et al. Pilocytic astrocytoma [Electronic resource] // Radiopaedia.org. DOI: 10.53347/rID-1876 (дата обращения: 18.10.2026). 5. Giannini C., Paulus W., Louis D.N., Liberski P. Pleomorphic xanthoastrocytoma // WHO Classifica-tion of Tumours of the Central Nervous System / ed. by D.N. Louis, H. Ohgaki, O.D. Wiestler, W.K. Cavenee. 4th ed. Lyon: IARC Press, 2007. P. 22–24. 6. Kepes J.J., Rubinstein L.J., Eng L.F. Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis. A study of 12 cases // Cancer. 1979. Vol. 44, № 5. P. 1839–1852. DOI: 10.1002/1097-0142(197911)44:5<1839::AID-CNCR2820440543>3.0.CO;2-0. 7. Mathkour M., Banerjee S., Werner C., Hanna J., Abou-Al-Shaar H., Dindial R., et al. Cerebellar ple-omorphic xanthoastrocytoma in the setting of neu-rofibromatosis type-I: does it portend a different prognosis? A case report and systematic review // Clinical Neurology and Neurosurgery. 2021. Vol. 200. Art. 106346. DOI: 10.1016/j.clineuro.2020.106346. 8. Wasdahl D.A., Scheithauer B.W., Andrews B.T., Jeffrey R.A. Cerebellar pleomorphic xanthoastrocy-toma: case report // Neurosurgery. 1994. Vol. 35, № 5. P. 947–951. DOI: 10.1227/00006123-199411000-00022.