Журнал кардиореспираторных исследований 2026. №2/3

Тема статьи

Erkaklarda prolaktin sekretsiyasi buzilishlarining reproduktiv va andrologik oqibatlari (53-55)

Авторы

G.Sh. Negmatova, Z.A. Xalbayeva

Учреждение

Samarqand davlat tibbiyot universiteti

Аннотация

Ushbu maqolada erkaklarda prolaktin (PRL) sekretsiyasining buzilishlari — giperprolaktinemiya va gipoprolaktinemiya — hamda ularning reproduktiv va andrologik funksiyalarga ta’siri kompleks tahlil qilingan. Maqolada prolaktinning gipotalamo-gipofizar-gonadal tizimdagi o‘rni, xususan steroidogenez, spermatogenez, testosteron sintezi va Leydig hamda Sertoli hujayralari faoliyatiga ta’siri keng yoritilgan. PRL sekretsiyasining buzilishi bilan bog‘liq klinik holatlar, jumladan gipogonadizm, bepushtlik, erektil disfunktsiya, libido pasayishi, shuningdek psixoemotsional va metabolik o‘zgarishlar tahlil qilingan. 2010–2025 yillar oralig‘idagi zamonaviy ilmiy manbalar asosida prolaktinning metabolik sindrom, insulinrezistentlik va prostata kasalliklari bilan bog‘liqligi ko‘rsatib berilgan. Diagnostik yondashuvlar sifatida prolaktin darajasini gonadotrop gormonlar va androgenlar bilan birgalikda baholashning ahamiyati ta’kidlangan. Davolashda dopamin agonistlari va individual yondashuv asosiy o‘rin tutishi qayd etilgan. Prolaktin erkaklar reproduktiv salomatligining muhim biomarkeri sifatida baholanadi va ushbu yo‘nalishda qo‘shimcha ilmiy tadqiqotlar o‘tkazish zarurligi asoslab berilgan.

Ключевые слова

prolaktin, giperprolaktinemiya, gipoprolaktinemiya, spermatogenez, androgenlar, testosteron, erkak bepushtligi, prostate

Литературы

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