Журнал кардиореспираторных исследований 2026. №2/3
Тема статьи
Clinical and pathogenetic aspects of osteoporosis development in women (102-105)
Авторы
G.Z. Shodikulova, O.F. Shamsiev
Учреждение
Samarkand State Medical University
Аннотация
One of the primary systemic skeletal diseases is osteoporosis, which is characterized by a decrease in bone strength that leads to an increased risk of fractures. Bone strength is determined by a combination of quantitative and qualitative characteristics, such as bone mineral density (BMD), bone turnover, and bone mineralization. Due to the gradual progression of the disease, osteoporosis is often diagnosed only after a fracture has occurred, which is why it is called a "silent epidemic." The data obtained indicate population-specific features of BMD in women and will help improve the quality of diagnostics for osteoporotic changes, allowing for the early and timely initiation of adequate OP therapy. Therefore, the purpose of our study was to investigate the features of the development and clinical course of osteoporosis in middle-aged women.
Ключевые слова
bone tissue, osteoporosis, pathogenesis and clinical presentation of osteoporosis.
Литературы
1. Бадалов, Н. Г. Роль немедикаментозных методов в комплексе мероприятий по профилактике и лечению остеопороза (обзор литературы) / Н. Г. Бадалов, А. Л. Кончугова, Т. В. Марченкова, Л. А. Персиянова-Дуброва, Е. Ю. Мартынова // Современная ревматология. – 2016. – Т. 10. – № 3. – C. 62-68. 2. Хусаинова, Р. И. Генетика остеопороза / Р. И. Хусаинова, Э. К. Хуснутдинова. – Уфа: Гилем, 2015. – 392 с. 3.Михайлов Е. Е., Беневоленская Л.И. Эпидемиология остеопороза и переломов // Руководства по остеопорозу / под ред. Л.И. Беневоленской. Москва: БИНОМ. Лабаратория знаний 2003.с.24-27. 4.Захаров И. С. Оценка согласованности результатов различных методов остеоденсометрии в диагностике остеопороза у женщин // Политравма. 2015 № 2. С. 120-121. 5. Osterhoff, G. Bone mechanical properties and changes with osteoporosis/G. Osterhoff, E. F. Morgan, S. J. Shefelbine et al. // Injury. – 2016. – V. 47. – P. S11- S20. 6. Wright, N. C. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine /N. C. Wright, A. C. Looker, K. G. Saag et al. // Journal of Bone and Mineral Research. – 2014. – V. 29. – № 11. – P. 2520-2526. 7. Report on the adult on burden of osteoporosis in eight countries of the Eurasian Region: Armenia, Belarus, Georgia, Moldova, Kazakhstan, the Kyrgyz Republic, the Russian Federation, and Uzbekistan // Arch.Osteoporos.2020. Vol. 15. P. 175. DOI: 10.1007/ s11675-020-00836-y. 8. Sozen, T. An overview and management of osteoporosis / T. Sozen, L. Ozisik, N. C. Basaran // European Journal of Rheumatology. – 2017. – V. 4. – № 1. – P. 46-56. 9. Ghayor, C. Epigenetic regulation of bone remodeling and its impacts in osteoporosis / C. Ghayor, F. E. Weber // International Journal of Molecular Sciences. – 2016. – V. 17. – № 9. – P. 1446. 10. Panday, K. Medication-induced osteoporosis: Screening and treatment strategies / K. Panday, A. Gona, M. B. Humphrey // Therapeutic Advances in Musculoskeletal Disease. – 2014. – V. 6. – P. 185-202. 11. Cosman, F. Clinician’s Guide to Prevention and Treatment of Osteoporosis / F. Cosman, S. J. de Beur, M. S. LeBoff et al. // Osteoporosis International. – 2014. – V.25. – № 10. – P. 2359-2381. 12. Alswat, K. A. Gender Disparities in Osteoporosis / K. A. Alswat // Journal of Clinical Medicine Research. – 2017. – V. 9. – № 5. – P. 382- 387. 13. Zhu, D. L. Multiple Functional Variants at 13q14 Risk Locus for Osteoporosis Regulate RANKL Expression Through Long-Range Super-Enhancer / D. L. Zhu, X. F. Chen, W. X. Hu et al. // Journal of Bone and Mineral Research. – 2018. – V. 33. – 14. Sterling, R. S. Gender and race/ethnicity differences in hip fracture incidence, morbidity, mortality, and function / R. S. Sterling // Clinical Orthopaedics and Related Research. – 2011. – V. 469. – № 7. – P. 1913–1918. 15. Kamolidinovna T. Z., Zikriyaevna S. G. RISK FACTORS AND FEATURES OF CORONARY HEART DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS //JOURNAL OF BIOMEDICINE AND PRACTICE. – 2022. – Т. 7. – №. 6. 16. Ralston, S. H. Genetics of osteoporosis / S. H. Ralston, A. G. Uitterlinden // Endocrine Reviews. – 2010. – V. 31. – № 5. – P. 629-662. 17. Shodikulova G. Z. et al. The Correlation among Osteoporosis, Calcium-Phosphore Metabolism and Clinical Symptoms of Main Disease in Patients with Rheumatoid Arthritis //Annals of the Romanian Society for Cell Biology. – 2021. – С. 4185-4190