Журнал кардиореспираторных исследований 2025. №2/2

Тема статьи

TIZIMLI QIZIL YUGURIK KASALLIGIDA ANEMIK SINDROM PATOGENEZI XUSUSIYATLARI (28-32)

Авторы

Mamatkulova Feruza Xaydarovna, Maxmonov Lutfulla Saydullayevich, Azizova Shaxlo Majidovna, Yarmatova Moxina Soli qizi, Xo‘rozov Maxsud Maxmudovich

Учреждение

Samarqand Davlat Tibbiyot universiteti, Samarqand viloyat ko‘p tarmoqli tibbiyot markazi

Аннотация

Anemik sindrom tizimli qizil yuguruk (TQY) ning eng keng tarqalgan ko‘rinishlaridan biri bo‘lib, asosiy kasallikning kechishini og‘irlashtiradi va uni davolashni sezilarli darajada murakkablashtiradi [7]. Adabiyot ma’lumotlariga ko‘ra, TQYU da anemiya sindromining (AS) tarqalishi 1,4% dan 80% gacha [2, 5, 8].Tizimli qizil yugurukda (TQYU) anemik sindromining (AS) tarqalishi va patogenetik mexanizmlarini o‘rganish uchun 44 bemorda temir almashinuvi, gemoliz va yallig‘lanish parametrlari o‘rganildi. Bemorlarning 75 foyizida anemiya mavjud bo‘lgan: surunkali temir tanqisligi anemiyasi, "yallig‘lanish kasalligi" anemiyasi, normoxromik tashxis qo‘yilgan; Barcha holatlarda klinik gemoliz belgilari mavjud edi. Anemik sindrom ko‘pincha tizimli qizil yuguruk faolligining yuqori darajasi bilan bog‘liq edi. Tizimli qizil yuguruk dagi AS patogenezi juda murakkab va to‘liq tushunilmagan. Eng tez-tez kuzatiladigan rivojlanish autoimmun gemolitik anemiya (AIGA), ko‘pincha tizimli qizil yuguruk boshlanishida trombotsitopeniya [8,9,10] bilan birgalikda, eritrotsitlarga antitanalarning ishlab chiqarilishi natijasida "autoimmun gemolitik niqob" [5] sifatida rivojlanadi. Biroq, TQYU da autoimmun gemolitik anemiya ko‘p hollarda klinik va laborator o‘zgarishlar mavjud bo‘lmaydi, gemolizning simptom kompleksi, ijobiy Kumbs testi esa, ba’zi mualliflarning fikriga ko‘ra, tez-tez aniqlanadi. Bularning barchasi ushbu holatni tashxislashni juda qiyinlashtiradi.

Ключевые слова

Tizimli qizil yuguruk, temir tanqisligi anemiyasi, autoimmun gemolitik anemiya, anemic sindrom, surunkali kasalliklar anemiyasi.

Литературы

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