Биология ва тиббиёт муаммолари 2025, №4 (163)
Тема статьи
ROLE OF INFLAMMATORY BIOMARKERS IN PEDIATRIC ACUTE LEUKEMIAS: INSIGHTS FOR DIAGNOSIS, MONITORING, AND PROGNOSIS (247-250)
Авторы
Khodjaeva Nikzan Nazarbekovna, Sodikov Naimzhon Makhmadaminovich, Makhfuzulloh Azimi, Khojaeva Farangis Murodovna, Berger Inna Viktorovna, Rasulova Nodira Alihserovna
Учреждение
1 - State Educational Institution "Tajik State Medical University named after Avicenna ", Republic of Tajikistan, Dushanbe; 2- Farabi Medical Center, Republic of Tajikistan, Dushanbe; 3 - Republican Scientific and Practical Medical Center of Hematology, Ministry of Health of the Republic of Uzbekistan, Tashkent; 4 - Samarkand State Medical University, Republic of Uzbekistan, Samarkand
Аннотация
A prospective cohort study of 50 children with newly diagnosed AL (60% ALL, 40% AML) was conducted from 2023 to 2025. Biomarker levels were measured at baseline, day 14, and day 28 of therapy using biochemical assays and chemiluminescent immunoassays (CLIA). Statistical analysis was performed using SPSS v26.0, with significance set at P< 0.05. At baseline, children with AL showed significantly elevated levels of HA (2.8 ± 0.6 mg/L vs 1.1 ± 0.2 mg/L in controls), PCT (0.96 ± 0.24 ng/mL in ALL, 1.12 ± 0.31 ng/mL in AML vs 0.03 ± 0.02 ng/mL in controls), and IL-6 (35 ± 8 pg/mL in ALL, 45 ± 10 pg/mL in AML vs 3 ± 1 pg/mL in controls). Therapy led to a progressive decline in these markers, correlating with clinical improvement. Monitoring inflammatory biomarkers in pediatric AL enhances early diagnosis, risk stratification, and treatment evaluation, supporting a personalized approach to therapy.
Ключевые слова
Pediatric acute leukemia, inflammatory biomarkers, hyaluronic acid, procalcitonin, interleukins, prognosis.
Литературы
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