Gepato-gastroenterologik tadqiqotlar jurnali 2021, № 4
Subject of the article
CLINICAL AND EPIDEMIOLOGICAL FEATURES IN PEDIATRIC PATIENTS IN WITH SARS-COV-2 INFECTION IN THE RYAZAN REGION (81-87)
Authors
Belykh N.A. , Nataliya A. Anikeeva, Anastasia Yu. Panferuhina, Inna V. Piznjur
Institution
Ryazan State Medical University named after acad. I.P. Pavlov
Abstract
To study the clinical and laboratory features of the course of SARS-CoV-2 infection (COVID-19) in children of the Ryazan region. A retrospective study carried out with the participation of 55 children hospitalized at the City Clinical Hospital No. 11 (Ryazan) from April 2020 to March 2021 with a diagnosis of new coronavirus infection COVID-19. Among those hospitalized, there was a predominance of children over the age of 12 years (61.8%). Almost one third of patients had comorbid pathology. The most common comorbidities were obesity, CVS and CNS pathology. More than half of the hospitalized children (58.2%) had intrafamilial contact with laboratory-confirmed cases of COVID-19. The main clinical manifestations in the observed children were: symptoms of intoxication, respiratory tract lesions and gastrointestinal symptoms. In the dominant number of cases (63.6%), lung damage corresponded to mild (CT-1) severity. More than half of the children (63.6%) had a concomitant bacterial infection. IgM antibodies to Mycoplasma pneumoniae were detected by ELISA in 15 patients (27.3%). A direct correlation was found between the degree of lung damage and the level of CRP (r = 0.31, p = 0.019), ALT (r = 0.30, p = 0.05) and LDH (r=0.27, p = 0.05), as well as the presence of concomitant diseases (r = 0.41, p = 0.002). Against the background of the therapy, positive dynamics was noted in the condition of all patients. Lethal outcomes not recorded in the studied sample of patients. Almost half of the patients (40%) had a comorbid pathology. The presence of concomitant bacterial infection was detected in 63.6% of children. Most patients are diagnosed with respiratory mycoplasmosis. A significant positive correlation was established between the degree of damage to the lung tissue and the presence of concomitant diseases, as well as deviations from the norm of a number of laboratory parameters (CRP, ALT, LDH). With timely treatment, most patients with viral lung disease caused by the new coronavirus infection COVID-19 had a favorable outcome of the disease.
Key words
Key words: new coronavirus infection, viral lung disease, community-acquired pneumonia,
Literature
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