Kardiorespirator tadqiqotlar jurnali. Maxsus son. 2022
Subject of the article
ROLE AND EFFECT OF GLUTATHIONE DEFICIENCY IN THE POST-COVID PERIOD (651-657)
Authors
Nurillaeva N.M., Omarov K.B., Khasanova N.A.
Institution
Tashkent medical academy
Abstract
Many people who have been ill with coronavirus, even in a mild form, note that they experience various negative sensations in the body even months after recovery. Currently, a specialized term has appeared to define this condition - post-covid syndrome. Purpose study of the features of the clinical course of the post-COVID period and the effect of the complex use of glutathione on the recovery period of patients who underwent COVID-19.Material and methods. The clinical condition of 58 patients with COVID - 19 who arrived for inpatient treatment at the cardiology department of the TMA multidisciplinary clinic, 20-30 days after the disappearance of symptoms of coronavirus infection, was analyzed. Several pieces of evidence presented in our biochemical analysis suggest that low GSH levels may be one of the main causes of the excessive inflammatory response associated with severe COVID-19 symptoms and indicate that an increase in GSH in the body may reduce the number of symptomatic patients. Future clinical studies of GSH levels in patients with COVID-19 may be a starting point to explore this possibility
Key words
post-COVID syndrome, glutathione, coronavirus, COVID-19.
Literature
1. Callard F., Perego E.: How and why patients made Long Covid. Soc. Sci. Med., 2021; 268: 113 426. doi: 10.1016/j.socscimed.2020.113 426 2. Ceriello A., Giugliano D., Quatraro A., Lefebvre P.J. Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects. Clin. Sci. 1991;81:739–742. doi: 10.1042/cs0810739. 3. He Y., Yue Y., Zheng X., Zhang K., Chen S., Du Z. Curcumin, inflammation, and chronic diseases: How are they linked? Molecules. 2015;20:9183–9213. doi: 10.3390/molecules20059183. 4. Vera M., Torramade-Moix S., Martin-Rodriguez S., Cases A., Cruzado J.M., Rivera J., Escolar G., Palomo M., Diaz-Ricart M. Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease. Cell. Physiol. Biochem. 2018;51:1287–1300. doi: 10.1159/000495540 5. Wu T., Gao Y., Guo X., Zhang M., Gong L. Blackberry and Blueberry Anthocyanin Supplementation Counteract High-Fat-Diet-Induced Obesity by Alleviating Oxidative Stress and Inflammation and Accelerating Energy Expenditure. Oxid. Med. Cell Longev. 2018;2018:4051232. doi: 10.1155/2018/4051232. 6. Zinellu A., Zinellu E., Sotgiu E., Fois A.G., Paliogiannis P., Scano V., Piras B., Sotgia S., Mangoni A.A., Carru C., et al. Systemic transsulfuration pathway thiol concentrations in chronic obstructive pulmonary disease patients. Eur. J. Clin. Investig. 2020:e13267. doi: 10.1111/eci.13267. 7. https://www.ons.gov.uk/news/statementsandletters/theprevalenceoflongcovidsymptomsandcovid19 complications8. https://belsono.by/articles/postkovidnyy-sindrom/ 9. https://stopcovid19.com.ru/ 10. https://www.sciencedirect.com/science/article/pii/S2213007120301350. 11. https://clinicaltrials.gov/ct2/show/study/NCT04374461