Biomeditsina va amaliyot jurnali, 2022 №3
Subject of the article
METHODS OF HISTOLOGICAL EXAMINATION OF DIABETES MELLITUS IN THE LUNG ENDOTHELIUM (381-385)
Authors
SOBIROVA Dildora Ravshanovna USMANOV Ravshanbek Djaxangirovich AZIZOVA Feruza Xusanovna
Institution
Toshkent tibbiyot akademiyasi
Abstract
Qandli diabetning tibbiy-ijtimoiy ahamiyati kasallikning tobora ortib borishi, shuningdek, mehnatga layoqatli yoshdagi bemorlarning hayot faoliyatini pasaytirishi va qon tomir asoratlarining rivojlanishi bilan belgilanadi. Hozirgi vaqtda qon tomir endoteliyasi ko'p vazifalarni bajaruvchi a’zo ekangili aniqlasngan. Endotelial hujayralar metabolik faol bo'lib, fiziologik sharoitda qon tomir gomeostazini saqlash uchun zarur bo'lgan parakrin, endokrin va avtokrin funksiyalarga ega. Endoteliy funksiyalariga qon tomirlarining yaxlitligi va o'tkazuvchanligini, angiogenezni, gemostazni tartibga solish kiradi. Bunday asoratlarga mikroangiopatiyalar, shu jumladan nefro-, retino- va neyropatiyalar, shuningdek, makroangiopatiyalar, shu jumladan yurak-qon tomir kasalliklari va serebrovaskulyar kasalliklar kiradi, ularning rivojlanishi uchun qandli diabetni aniqlangan xavf omilidir. Qandli diabetda angiopatiyalarning rivojlanish mexanizmi ko'p faktorli, ammo ko'pchilik tadqiqotchilar patologik reaktsiyalar majmuasini, jumladan fermentativ bo'lmagan glikozillanish, oksidlovchi stress va yallig’lanishni qo'zg’atuvchi giperglikemiya ularning paydo bo'lishi va rivojlanishining asosiy bo'g'ini hisoblanadi
Key words
qandli diabet, endotelial disfunktsiyaning rivojlanishi, angiogen funsiyalar
Literature
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