Biomeditsina va amaliyot jurnali, 2022 №4


Subject of the article

INTERRELATION BETWEEN THE NERVOUS AND IMMUNE SYSTEMS IN CHILDREN WITH RHEUMATOID ARTHRITIS (literature review) (200-209)

Authors

KHAMIDOVA Nodira Abdujabbarovna Tashkent Pediatric Medical Institute

Institution

Tashkent Pediatric Medical Institute

Abstract

Ювенил ревматоид (идеопатик) артрит неврологик асоратларга олиб келиши мумкин бўлган ревматик касалликлар гуруҳига киради, шунингдек, психо-эмоционал ва когнитив доира бузилишларига олиб келади. ЮРАдаги асаб тизимининг шикастланишига турли хил сабабли келиб чиққан бош оғриқлари, вегетатив дисфункция, астено-невротик кўринишлар, когнитив функциянинг бузилиши, кам ҳолларда нейропатиялар, орқа мия ва периферик нервларнинг сиқилиши(туннел синдромлар) ҳамда жуда кам ҳолларда мия васкулитларига олиб келади. Бироқ МНСининг бузилиши белгиларини аниқлаш ЮРА билан оғриган беморларда қийин кечади, чунки касалликнинг клиникасида бўғим ва ички органлар фоалияти бузилиши белгилари устунлик қилади. Калит сўзлари: Ювенил ревматоид (идеопатик) артрит, нерв (асаб) ва иммун тизими, вегетатив дисфункция.

Key words

Калит сўзлари: Ювенил ревматоид (идеопатик) артрит, нерв (асаб) ва иммун тизими, вегетатив дисфункция.

Literature

1. Abramov V.V. Integration of the immune and nervous systems. The science. 1991. 168 p. 2. Abstract (“Features of the current course of juvenile idiopathic arthritis in children and adolescents (clinic, diagnosis, treatment, Candidate of Medical Sciences Filipenkova, Natalia Alexandrovna, 2005). 3. Alekseeva E.I., Litvitsky P.F. Juvenile rheumatoid arthritis: etiology, pathogenesis, clinic, diagnostic and treatment algorithms. Ruk. for doctors, teachers, researchers / Ed. ed. A.A. Baranov. M.: VEDI; 2007: 308 4. Badokina Sh.B. //Rheumatology //Clinical lectures. / Moscow5. Belyaeva L.M. Pediatric cardiology and rheumatology: A practical guide. - M .: LLC "Medical Information Agency", 2011. - 584 p. 6. Belyaeva L.M. Modern approaches to the treatment of rheumatic diseases in children // International Journal of Pediatrics, Obstetrics and Gynecology. - 2013. - V. 3, No. 3. - S. 25- 34. 7. P. A. Vorobyov, E. I. Alekseeva, and L. Yu. Study of the epidemiology, drug therapy and functional status of patients with juvenile rheumatoid arthritis in Russia. Clinical pharmacology and pharmacoeconomics 2011; (4): 74–7. 8. Genetic predisposition to rheumatoid arthritis: the role of HLA class I genes and haplotypes / Т.А. Suslova, A.L. Burmistrova, E.B. Khromova [et al.] // Immunology. 2008, vol. 29, no. 3, pp. 137–141. 9. Selected lectures on pediatrics / Ed. A.A. Baranova, R.R. Shilyaeva, B.S. Kaganov. - M .: Publishing house "Dynasty", 2005. - 640 p. 10. Kaleda M.I., Nikishina I.P., Rodionovskaya S.R. Clinical observation of the use of tocilizumab in refractory systemic juvenile arthritis with lung damage and macrophage activation syndrome // Scientific and Practical Rheumatology. - 2015. - T. 53, No. 4. - S. 446-451. 11. Cardiology and rheumatology of childhood: A guide for doctors / Ed. G.A. Samsygina, M.Yu. Shcherbakova. — M.: Medpraktika, 2004. — 744 p. 12. Курьязова Ш.М., Худайназарова С.Р., Собирова Э.А. Реактивные артриты у детей школьного возраста, Сборник тезисов «Дни ревматологии в Санкт-Петербурге» 2020 13. Болтобаев С.А., Азизов С.В., Азизова Р.И., Азизов Н.Н. Влияние танцевальных упражнений на показатели иммунной защиты реабилитации больных ревматоидным артритом, Сборник тезисов «Дни ревматологии в Санкт-Петербурге» 2020 14. Kulik M.S., Barzilovich V.D., Minchenko A.P. Rheumatoid arthritis: Peculiarities of etiopathogenesis // Ukrainian Scientific Medical Youth Journal. - 2012. - No. 1. - S. 71-74. 15. Kravtsova O.N., Bagirova G.G. Epidemiology of arthritis in adolescents. Actual problems of modern rheumatology. Collection of scientific works. Ed. academician o16. Mazurov V.I., Belyaeva I.B., Dolgikh S.V. Innovative methods of treatment of systemic autoimmune diseases. Honey. academic journal. 2009. No. 4. S. 96-106. 17. Methodical instructions for independent work of students in preparation for practical (seminar) employment “Differential diagnosis of globule syndrome in children. Juvenile rheumatoid arthritis, reactive arthritis. – Vinnytsia National Medical University named after. M.I. Pirogova, 2014. - 50 p. 18. Nasonova V.A. //Rheumatology. / Study 2009 pp 8 6 -8 9 . 19. Nikitin Z. Interaction between the nervous and immune systems. breast cancer. 1996. No. 2. S. 9-13. 20. Novikov A.A., Aleksandrova E.N., Cherkasova M.V., Nasonov E.L. Modern methods of laboratory diagnosis of rheumatoid arthritis // Nauch.‑prakt. rheumatol. 2010. No. 1. P. 31–45 21. Long-term outcomes of rheumatoid arthritis depending on the timing of the start of therapy with basic anti-inflammatory drugs / G.R. Imametdinova, N.V. Chichasova, M.Z. Kanevskaya [et al.] // Nauch.‑prakt. rheumatol. 2010. No. 3. S. 23–31. 22. Petrukhin A.S. //Children's neurology. /Textbook. / Moscow 2012 volume 2, pp. 396-397 23. Petrukhin A.S. // Children's neurology. /Textbook. / Moscow 2012 volume 2, pp. 498-500. 24. Рейтмаєр М.Й. Ювенільний ревматоїдний артрит: сучасні термінологічні, класифікаційні та діагностичні розбіжності // Архів клінічної медицини. — 2012. — № 2. — С. 91-94. 25. Salugina S.O. Nosological diagnosis of juvenile arthritis at different stages of observation. Modern Rheumatology. - 2010. - No. 3. - S. 22-28. 26. Toirov E.S. // Borderline neuropsychiatric disorders in patients with JRA. /27. Filatova E.S., Erdes Sh.F. //Etiopathogenetic factors of peripheral neuropathic pain in rheumatoid arthritis. /Journal of Neurology and Psychiatry. S.S. Korsakov. 2017;117(8):67-71. doi:10.17116/jnevro20171178167-71 28. Filatova E.S., Lila A.M., Parfenov V.A. // Neuropathic pain in rheumatoid arthritis. /Neurology, neuropsychiatry, psychosomatics.2020;12(5):60–65. DOI: 10.14412/2074-2711- 2020-5-60-65 29. Folomeeva O.M., Amirdzhanova V.N., Erdes Sh.F. Validation of the functional activity index of a patient with rheumatoid arthritis (PAS) // Nauch.-prakt. rheumatol. 2007. No. 4. S. 89–96 30. Shabalov N.P. //Childhood diseases. / Publishing house "Peter", 2006 volume 2. Pp. 92-93. 31. Shabalov N.P. //Childhood diseases. / Publishing house "Peter", 2006 volume 2. Pp. 83. 32. Shilkina N.P., Spirin N.N., Dryazhenkova I.V. Diagnosis and treatment 33. lesions of the nervous system in rheumatic diseases. Attending doctor. 2009. No. 4. S. 26-29. 34. 5. Yakhno N., Shtulmana D.R. // Diseases of the nervous system. / Guide for doctors. Volume II 2003 pp. 378-379 35. Yakhno N., Shtulmana D.R. // Diseases of the nervous system. Volume II. / Guide for doctors. 2003 gstr 377 -378 36. Andersson, G.B. Epidemiology of rhematic disease in children / G.B. Andersson // Zur Zeitschrifi fur Rhematologie. 2000. — Bd. 59: Abstracts des 29 Kongresse der Deutschen Gesellschaft fur Rheumatologie. — S. 3. 37. Agarwal V, Singht R, Wiclaf, et al. A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis. Clin Rheumatol. 2008 Jul;27(7):841-4 doi: 10.1007/s10067- 007-0804-x. Epub 2007 Dec 15. 38. Bayrak A.O., Durmus D, Durmaz Y, et al. Electrophysiological assessment of polyneuropathic involvement in rheumatoid arthritis: relationship among demoraphic, clinical and laboratory findings. Neurol Res. 2010;32:711-4. doi: 10.1179/016164109x12581096870195 39. Epidemiology of juvenile spondyloarthropathies in Spanish hospital/ C.Castro —Villegas, R. Roldan, V.C. Perez et al. // EULAR–2004 40. Cassidy J.T. et al. Textbook of pediatric rheumatology. — 6th ed. — Philadelphia: Saunders Elsevier, 2010. — 794 р. 41. Horneff G. Juvenile arthritides // Z. Rheumatology. — 2010. — Vol. 69, № 8. — P. 719-736. 42. Interleukin-6 as a key player in systemic inflammation and joint destruction / J.E. Foseca, M. J. Santos, H. Canhao [et al.] // Autoimmune Rev. 2009. № 10. P. 1016. 43. Lee YC, Cui J, Lu B, et al. Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study. Arthritis Res Ther. 2011 Jun8;13(3):R83. doi: 10.1186/ar3353 44. Lanzillo B, Psappone N, Criscil C, et al. Subclinical peripheral nerve involvement in patients with rheumatoid arthritis. Arthritis Rheum. 1998; 41:1196-202.doi:10.1002/1529- 0131(199807)41:7<1196::AIDART8>3.0.CO;2-R 45. Petty R.E. et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001 // Journal of Rheumatology. — 2004. — Vol. 31. — P. 390-392. 46. Roony M. et al. Tumor necrosis factor alpha and it soluble receptor in juvenile chronic arthritis // Rheumatology. — 2000. — Vol. 39. — P. 432-438. 47. Shahin A.A. et al. Circulating interleukin-6, soluble interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-10 levels in juvenile chronic arthritis: correlations with soft tissue vascularity assessed by power Doppler sonography // Rheumatology Int. — 2002. — Vol. 22. — P. 8. 48. Stenberg E.M. Neuroendocrine regulation of autoimmune /inflammatory