Kardiorespirator tadqiqotlar jurnali. Maxsus son. 2022

Subject of the article



Sultonov I.I., Ibragimov K.I., Ziyadullayev Sh.K.


Samarkand State Medical University


Background. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease Objective. To explore the risk factors proposed to be associated with the development of SLE. Material and methods. In total 72 cases and 142 matched controls were interviewed between 2008 and 2019 at the first Clinic of Samarkand State Medical Institute. Only those patients who met >4 criteria for SLE were included in the study. The questionnaire consisted of questions related to risk factors were developed. The effect of the exposure variables on SLE was measured using the odds ratio (OR) and its 95% confidence interval (CI). Results. Using a multivariate model, cases with a history of hypertension tended to have an increased risk of SLE development (OR 3.7, 95% CI 1.36-7.9). Also, cases were more likely to report angina pectoris than controls (OR 4.7, 95% CI 1.6-24). There was a statistically significant association between a family history of any autoimmune disease and an increased risk of SLE (OR 2.25, 95% CI 1.25-4.05). While those who smoke 2 to 5 cigarette packs per week had 2.64 times increased risk of SLE compared to non-smokers (OR = 2.64, 95% CI 0.97-7.18). However, none of the results on this exposure was statistically significant. Conclusions. SLE may be associated both with endogenous and exogenous factors as well. Additional well-designed studies are needed to explore a cause-and-effect relationship between these factors and SLE.

Key words

Lupus, SLE, risk factors, smoking, alcohol, stress, family history.


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