Журнал кардиореспираторных исследований. Special Issue 1.1.(сборник статей)

Subject of the article

IDENTIFICATION OF NEW GENETIC AND IMMUNOLOGICAL BIOMARKERS OF SEVERE BROCHIAL ASTHMA AS A CURRENT PROBLEM (99-106)

Authors

Sh.X. Ziyadullaev., J.A. Ismailov.

Institution

Samarkand State Medical University

Abstract

There are 300 million asthma sufferers globally, and the mortality rate ranges from 0% to 18%. Worldwide, bronchial asthma (BA), which has a prevalence of 1 to 18 percent, is becoming more common. According to the updated (GINA-2017) definition, asthma is categorized as a diverse airway condition that is typically characterized by persistent airway inflammation. It is characterized by a history of airway blockage and respiratory symptoms such wheezing, shortness of breath, chest congestion, and cough, with variable onset, frequency, and intensity. In recent years, significant and numerous successes in the treatment of bronchial asthma have been achieved. These results are associated with the significant effectiveness of inhaled corticosteroids in the topical diagnosis and pathogenetic treatment of bronchial asthma. However, despite the results achieved, the fight against this disease is not satisfactory. In patients with severe bronchial asthma, inhaled corticosteroids are more effective when used in combination with β2-agonists. Almost every second patient with asthma is concerned about nocturnal attacks. More than half of the patients had limited physical activity, and one in three lost the ability to work. Most patients are forced to see a doctor because of the exacerbation and progression of the disease.

Key words

bronchial asthma, biomarkers, immunology

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