Doktor axborotnomasi 2022, №1 (102)
Subject of the article
ТЕСТИРОВАНИЕ ВИРУСА ПАПИЛЛОМЫ ЧЕЛОВЕКА В ПЕРВИЧНОМ СКРИНИНГЕ ПАТОЛОГИИ ШЕЙКИ МАТКИ (158-161)
Authors
Д. З. Мамарасулова, Д. Б. Исакова, Г. Б. Абдуллахонова
Institution
Андижанский государственный медицинский институт, Андижан, Узбекистан
Abstract
В данной статье обсуждаются вопросы тестирования ВПЧ с помощью цитологического скрининга. Комбинация цитологии и ВПЧ тестирования считается основой скрининга. Эти методы дополняют друг друга, поскольку цитологическое исследование обладает высокой специфичностью, но низкой чувствительностью, в то время как ВПЧ тестирование, напротив, характеризуется низкой специфичностью и высокой чувствительностью.
Key words
рак шейки матки, скрининг, цитология.
Literature
1. Arbyn M, Ronco G, Anttila A, Meijer CJ, Poljak M, Ogilvie G, et al. Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer. Vaccine. 2012;30:F88–F99. [PubMed] [Google Scholar] 2. Bains, I., Choi, Y. H., Soldan, K., Jit, M. Clinical impact and cost-effectiveness of primary cytology versus human papillomavirus testing for cervical cancer screening in England. Int. J. Gynecol. Cancer ijgc-2018-000161 (2019). 3. Carestiato FN, Afonso LA, Moyses N, Almeida Filho GL, Velarde LG, Cavalcanti SM. An upward trend in DNA p16ink4a methylation pattern and high risk HPV infection according to the severity of the cervical lesion. Rev Inst Med Trop Sao Paulo. 2013;55(5):329–334. [PMC free article] [PubMed] [Google Scholar] 4. Meijer CJ, Berkhof J, Castle PE, Hesselink AT, Franco EL, Ronco G, et al. Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older. Int. J. Can-cer. 2009;124:516–520. [PMC free article] [PubMed] [Google Scholar] 5. O‘Connor M, O‘Leary E, Waller J, Gallagher P, Martin CM, O‘Leary JJ, et al. Socio-economic variations in anticipated adverse reactions to testing HPV positive: implications for the introduction of primary HPV-based cervical screening. Preventive Med. 2018;115:90–96. [PubMed] [Google Scholar] 6. Poljak M, Kocjan BJ. Commercially available assays for multiplex detection of alpha human papillomaviruses. Expert Rev. Anti Infect. Ther. 2010;8:1139–1162. [PubMed] [Google Scholar] 7. Ronco G, Dillner J, Elfstrom KM, Tunesi S, Snijders PJ, Arbyn M, et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled tri-als. Lancet. 2014;383:524–532. 8. Rebolj M, Rimmer J, Denton K, Tidy J, Mathews C, Ellis K, et al. Primary cervical screening with high risk human papillomavirus testing: observational study. BMJ. 2019;364:l240. 9. Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. American journal of obstetrics and gynecology. 2003;188:1383–92. 10. Schwarz TF, Galaj A, Spaczynski M, Wysocki J, Kaufmann AM, Poncelet S, et al. Ten-year immune persistence and safety of the HPV-16/18 AS04-adjuvanted vaccine in females vaccinated at 15–55 years of age. Cancer Med. 2017;6:2723–2731. [PMC free article] [PubMed] [Google Scholar] 11. Torres KL, Marino JM, Pires Rocha DA, de Mello MB, de Melo Farah HH, Reis R, D. S, et al. Self-sampling cou-pled to the detection of HPV 16 and 18 E6 protein: A promising option for detection of cervical malignancies in remote areas. PLoS ONE. 2018;13:e0201262. [PMC free article] [PubMed] [Google Scholar] 12. Tsuda H, Hashiguchi Y, Nishimura S, Kawamura N, Inoue T, Yamamoto K. Relationship between HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm. Gynecol Oncol. 2003;91(3):476–485. 13. Wright TC, Jr, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 consensus guidelines for the management of women with abnormal cervical screening tests. Journal of lower genital tract disease. 2007;11:201–22. 14. Yang H, Hu H, Gou Y, Hu Y, Li H, et al. Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma. Int J Clin Oncol. 2018;23:321–328. doi: 10.1007/s10147-017-1210-2. [PubMed] [CrossRef] [Google Scholar] 15. Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst. 2000;92(9):690–698. [PubMed] [Google Scholar]