Журнал кардиореспираторных исследований 2026. №2/3

Maqola mavzusi

Gut microbiota and rheumatoid arthritis: a literature review (88-91)

Mualliflar

Khasanov O.G., Khazratov N.M.

Muassasa

Samarkand State medical university

Annotatsiya

Rheumatoid arthritis (RA), a long-lasting autoimmune disease, is associated with changes in the gut microbiome. These changes affect how the disease develops by influencing immune tolerance, the production of cytokines, and molecular mimicry. This review examines specific gut microbiota characteristics in RA patients relative to healthy individuals, evaluating their correlation with biochemical and immunological indicators such as C-reactive protein (CRP), rheumatoid factor (RF), and cytokine profiles. A systematic literature search was performed using PubMed, Scopus, and Web of Science. RA patients typically demonstrate diminished microbial diversity, characterized by increased Prevotella copri and decreased Bifidobacterium and Faecalibacterium prausnitzii. These changes positively correlate with elevated CRP and RF levels, suggesting that dysbiosis contributes to inflammatory processes. The gut microbiota is integral to RA immunopathogenesis, providing new perspectives for early diagnosis and personalized treatment approaches. Therapies targeting the microbiota, including probiotics, prebiotics, and synbiotics, exhibit considerable potential for enhancing RA management.

Kalit so'zlar

Rheumatoid arthritis, gut microbiota, dysbiosis, immune modulation, Th17/Treg balance, cytokines, probiotics, prebiotics, microbiome therapy

Adabiyotlar

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