Журнал кардиореспираторных исследований 2025. №3

Maqola mavzusi

GENETIC SUSCEPTIBILITY TO OBESITY IN CHRONIC KIDNEY DISEASE: THE ROLE OF FTO (RS9939609) AND TNF (RS1800629) POLYMORPHISMS (34-39)

Mualliflar

Mirzaev Rizamat Ziyadullaevich, Nasirova Zarina Akbarovna

Muassasa

Samarqand davlat tibbiyot universiteti

Annotatsiya

The aim of this study was to investigate the association between FTO A23525T (rs9939609) and TNF G308A (rs1800629) polymorphisms and the development of obesity in patients with chronic kidney disease (CKD). DNA samples from 98 CKD patients (58 with obesity and 40 without obesity), as well as samples from healthy individuals, were analyzed. It was established that the T allele and the homozygous TT genotype of FTO A23525T are significantly associated with obesity in CKD patients, while the A allele and AA genotype have a protective effect. For the TNF G308A (rs1800629) polymorphism, an association between the G allele and GG genotype with CKD overall was revealed; however, no differences were found between subgroups regarding the presence of obesity. The obtained results emphasize the importance of genetic testing in a personalized approach to managing patients with CKD and obesity.

Kalit so'zlar

FTO rs9939609, TNF rs1800629, chronic kidney disease, obesity, genetic polymorphism, personalized medicine

Adabiyotlar

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