Биология ва тиббиёт муаммолари 2025, №4 (163)


Maqola mavzusi

ЗНАЧЕНИЕ НЕЙРОЭНДОКРИННОЙ СИСТЕМЫ ЛЕГКИХ ПРИ ПАТОЛОГИИ (299-304)

Mualliflar

Блинова Софья Анатольевна

Muassasa

Самаркандский государственный медицинский университет, Республика Узбекистан, г. Самарканд

Annotatsiya

В обзоре представлен анализ современных исследований нейроэндокринной системы легких при различных патологических состояниях органов дыхания. Установлена ее роль в развитии заболеваний легких у новорожденных и детей раннего возраста. Нейропептиды, выделяемые нейроэндокринными клетками и нейроэпителиальными тельцами, способствуют протеканию иммунных реакций. Нейроэпителиальные тельца содержат ниши для стволовых клеток. Доказана роль компонентов нейроэндокринной системы легких в регенерации бронхиального эпителия. Гиперплазия нейроэпителиальных клеток служит дополнительным источником гормонов при опухолевых и неопухолевых заболеваниях легких.

Kalit so'zlar

легкие, нейроэндокринная система легких, нейроэндокринные клетки, нейроэпителиальные тельца.

Adabiyotlar

1. Блинова С.А. Нейроэпителиальные тельца как звено легочной нейроэндокринной системы // ПБиМ, 2025, №3.1 (162). - 246-250 2. Блинова С.А., Хамидова Ф.М. Состояние эндокринного аппарата легких человека у онкологических больных // Проблемы биологии и медицины. -2023, №3 (144).- С.238-240. 3. Блинова С.А, Турсунов Х.З., Хамидова Ф.М. Особенности строения эндокринных структур АПУД-системы в легких у онкологических больных // Вестник ТМА. - 2021.-№ 2. –С. 87-89. 4. Blinova S. A., Oripov F. S., Yuldasheva N., Khamidova F. M.. Ismoilov J. M. Forming neuroendocrine apparatus of lung in ontogenesis // BIO Web of Conferences 65, 05015 (2023) 5. Branchfield K., Nantie L., Verheyden J.M., Sui P., Wienhold M.D., Sun X. Pulmonary neuroendocrine cells function as airway sensors to control lung immune response // Science. 2016; 351(6274):707-10. 6. Brouns I, Adriaensen D, Timmermans JP. The pulmonary neuroepithelial body microenvironment represents an underestimated multimodal component in airway sensory pathways. Anat Rec (Hoboken). 2025; 308(4):1094-1117. 7. Cutz E. Hyperplasia of pulmonary neuroendocrine cells in infancy and childhood // Semin Diagn Pathol. 2015; 32(6):420-37. 8. Cutz E, Pan J, Yeger H, Domnik NJ, Fisher JT. Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors. Semin Cell Dev Biol. 2013; 24(1):40-50. 9. Cutz E, Perrin DG, Pan J, Haas EA, Krous HF. Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction. Pediatr Dev Pathol. 2007; 10(2):106-16. 10. Garg A, Sui P, Verheyden JM, Young LR, Sun X. Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells // Curr Top Dev Biol. 2019;132:67-89. 11. Eenjes E, Benthem F, Boerema-de Munck A, Buscop-van Kempen M, Tibboel D, Rottier RJ. Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells. Cell Mol Life Sci. 2023;80(3):79. 12. Jiramethee N, Erasmus D, Nogee L, Khoor A. Pulmonary Neuroendocrine Cell Hyperplasia Associated with Surfactant Protein C Gene Mutation // Case Rep Pulmonol. 2017;2017:9541419. 13. Kuo CS, Krasnow MA. Formation of a Neurosensory Organ by Epithelial Cell Slithering. Cell. 2015 Oct 8;163(2):394-405. 14. Le Guen P, Poté N, Debray MP, Gounant V, Crestani B, Taillé C. L’hyperplasie neuroendocrine pulmonaire diffuse idiopathique (DIPNECH) [Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)]. Rev Mal Respir. 2025;42(5):262-273. 15. Lingamallu SM, Deshpande A, Joy N, Ganeshan K, Ray N, Ladher RK, Taketo MM, Lafkas D, Guha A. Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition. Cell Rep. 2024;43(9):114654. 16. Liu J, Song N, Tian S, Yu J. Neuroepithelial body increases in bleomycin-treated mice. Respir Physiol Neurobiol. 2014;193:52-4. 17. Livermore S, Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice. Adv Exp Med Biol. 2015; 860:309-13. 18. Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W. CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung. Cell Tissue Res. 2022;390(1):35-49. 19. Marchevsky AM, Walts AE. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) //Semin Diagn Pathol. 2015;32(6):438-44. 20. Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021;35(3):109011. 21. Noguchi M, Sumiyama K, Morimoto M. Directed Migration of Pulmonary Neuroendocrine Cells toward Airway Branches Organizes the Stereotypic Location of Neuroepithelial Bodies. Cell Rep. 2015;13(12):2679-86. 22. Ouadah Y, Rojas ER, Riordan DP, Capostagno S, Kuo CS, Krasnow MA. Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch // Cell. 2019 Oct 3;179(2):403-416.e23. 23. Pan J, Bishop T, Ratcliffe PJ, Yeger H, Cutz E. Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice //Hypoxia (Auckl). 2016;4:69-80. 24. Pan J., Yeger H. Chapter 21: Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase –1(PHD-1) Deficient Mice //Adv Exp Med Biol. 2012; 758: 149–155. 25. Samhouri BF, Halfdanarson TR, Koo CW, McCarthy C, Yi ES, Thomas CF, Ryu JH. DIPNECH: pragmatic approach, uncertainties, notable associations, and a proposal for an improved definition. Endocr Relat Cancer. 2023;30(10):e230051. 26. Schappe MS, Brinn PA, Joshi NR, Greenberg RS, Min S, Alabi AA, Zhang C, Liberles SD. A vagal reflex evoked by airway closure. Nature. 2024;627(8005):830-838. 27. Seeholzer LF, Julius D. Neuroendocrine cells initiate protective upper airway reflexes. Science. 2024; 384(6693):295-301. 28. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 Jan 1;371(6524):52-57. 29. Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. Pulmonary neuroendocrine cells amplify allergic asthma responses//Science. 2018 Jun 8;360(6393).8546. 30. Swied MY, Azhar W, Alkhabaz A, Zaidi F. Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: A Blanked Out Pulmonary Neuroendocrine Tumor. Case Rep Oncol. 2024 May 15;17(1):581-586. 31. Taweevisit M, Theerasantipong B, Taothong K, Thorner PS. Pulmonary Neuroendocrine Cell Hyperplasia in Hemoglobin Bart-induced Hydrops Fetalis: A model for Chronic Intrauterine Hypoxia. Pediatr Dev Pathol. 2017 Jul-Aug; 20 (4):298-307. 32. Thakur A, Mei S, Zhang N, Zhang K, Taslakjian B, Lian J, Wu S, Chen B, Solway J, Chen HJ. Pulmonary neuroendocrine cells: crucial players in respiratory function and airway-nerve communication. Front Neurosci. 2024 Aug 8;18:1438188. 33. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022 Apr 11;57(7):839-853. 34. Yancheva SG, Velani A, Rice A, Montero A. et al. Bombesin staining in neuroendocrine cell hyperplasia of infancy (NEHI) and other childhood interstitial lung diseases (chILD) // Histopathology.2015 Oct;67(4):501-8.