Doktor axborotnomasi 2025, №1.1 (118)

Maqola mavzusi

CLINICAL FEATURES OF THE COURSE ANTIBIOTIC-ASSOCIATED DIARRHEA IN CHILDREN (21-23)

Mualliflar

I. M. Akhmedova, A. T. Kamilova, Sh. S. Sultankhodjaeva, S. I. Geller

Muassasa

Center for the development of professional qualifications of medical workers, Tashkent, Republican specialized scientific and practical center of Pediatrics, Tashkent, Uzbekistan

Annotatsiya

The development of diarrhea during antibacterial therapy was observed in 27.2% of cases (40 children)out of 147 children. Diarrhea appeared on average 3.8±1.7 days after the start of antibiotic therapy. The average duration of antibiotic-associated diarrhea (AAD) was 5.3±1.8 days (ranging from 3 to 8 days). All patients presented with com plaints of diarrhea without blood but occasionally with mucus after starting antibiotic therapy. In 35% of cases (14 children), the disease was accompanied by vomiting 1 to 3 times a day. Additionally, 28 patients (70%) had com plaints of bloating. The average stool frequency was 4±2.3 times per day. The stool was watery, green, and contained undigested food particles.

Kalit so'zlar

antibiotic therapy, antibiotic-associated diarrhea, children.

Adabiyotlar

1. Yevstigneyev I.V. Immunological methods in the diagnosis of colon diseases. 2019: 22-32. 2. Zakharenko S.M., Ponomarev S.V. Diseases associated with *Clostridium difficile*: Treatment and prevention. 2017; 3:82-89. 3. Zakharova I.N., Mazankova L.N. Antibiotic-associated diarrhea in children: Problems and solutions (A guide for physicians). M., 2017. 4. Ivanko O.G. et al. Clinical aspects of antibiotic-associated diarrhea in children. Modern Pediatrics. 2015; 2(52):1 6. 5. Maidanik V.G., Khaytovich N.O., Boyarskaya L.N., et al. Treatment and prevention of *Clostridium difficile* induced AAD. Pediatrics, Obstetrics, Gynecology. 2018; 3. 6. Shcherbakov P.L., Tsvetkov P.M., Nechayeva L.V. Prevention of antibiotic-associated diarrhea in children. Con temporary Pediatrics. 2022; 3:2. 7. Turck J.P., Bemet J., et al. Incidence and risk factors of oral antibiotic-associated diarrhea in pediatric outpatients. J Pediatr Gastroenterol Nutr. 2021; 37(1):22-26. 8. Wistrom J., Norrby S.R., Myhre E.V., et al. Frequency of antibiotic-associated diarrhea in 2462 hospitalized pa tients: A prospective study. J Antimicrob Chemother. 2021; 47:43-50.