Doktor axborotnomasi 2025, №4 (121)

Maqola mavzusi

РОЛЬ ОКСИДАТИВНОГО СТРЕССА В РАЗВИТИИ ПОЧЕЧНОЙ ДИСФУНКЦИИ У ПАЦИЕНТОВ СО СТЕНОКАРДИЕЙ ДО И ПОСЛЕ АОРТОКОРОНАРНОГО ШУНТИРОВАНИЯ (107-115)

Mualliflar

М. А. Саидов, Н. В. Пирматова, Г. А. Кабилова

Muassasa

Национальный медицинский центр, Ташкент, Узбекистан

Annotatsiya

Оксидативный стресс (ОС) является ключевым патогенетическим механизмом развития почечной дис функции у пациентов со стенокардией, особенно в периоперационный период аортокоронарного шунтирова ния (АКШ). Избыточная генерация реактивных форм кислорода приводит к эндотелиальному повреждению, тубулярной гипоксии, нарушению микроциркуляции и активации провоспалительных цитокинов, что способ ствует формированию острого повреждения почек. В обзоре представлены современные данные о молекуляр ных звеньях ОС, его роли в ишемии-реперфузии, сравнительных особенностях on-pump и off-pump АКШ, а также диагностической значимости маркеров (МДА, СОД, цистатин С, гомоцистеин). Показано, что оценка маркеров ОС обладает высоким прогностическим потенциалом в раннем выявлении почечной дисфункции и выборе нефропротективных стратегий.

Kalit so'zlar

оксидативный стресс, стенокардия, аортокоронарное шунтирование, дисфункция почек, МДА, супероксиддисмутаза, цистатин С, ишемия-реперфузия.

Adabiyotlar

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