Doktor axborotnomasi 2025, №4 (121)

Maqola mavzusi

ROLE OF TRANSFORMING GROWTH FACTOR-Β1 IN THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE AND RENAL FIBROSIS (87-90)

Mualliflar

I. Sh. Bobojonov1, Z. Q. Xodjayeva2

Muassasa

1Tashkent state medical university, Tashkent, 2Urgench state medical institute, Urgench, Uzbekistan

Annotatsiya

Chronic kidney disease (CKD) is a progressive condition characterized by nephron loss, extracellular matrix (ECM) accumulation, and declining renal function. Transforming growth factor-β1 (TGF-β1) has been widely recog nized as a master regulator of fibrosis and is strongly implicated in the pathogenesis of CKD. Elevated TGF-β1 ex pression promotes glomerulosclerosis and tubulointerstitial fibrosis by stimulating collagen and fibronectin produc tion, thereby exacerbating structural damage and functional decline. Mechanistically, TGF-β1 activates the TβRII/ TβRI receptor complex, triggering downstream Smad-dependent signaling pathways that regulate transcription of pro fibrotic genes. Inhibitory Smad7 counterbalances this pathway, but its suppression leads to uncontrolled fibrogenesis. Beyond fibrosis, TGF-β1 plays multifaceted roles in kidney physiology, participating in immune regulation, epithelial to-mesenchymal transition, and tissue repair processes. Understanding these dual effects is essential for designing therapies that selectively block pathological TGF-β1 activity without disrupting its protective functions. This review summarizes current knowledge of TGF-β1 signaling in CKD and highlights potential therapeutic targets aimed at modulating its activity to prevent disease progression.

Kalit so'zlar

transforming growth factor-β1 (TGF-β1), chronic kidney disease, renal fibrosis, Smad signaling, glomer ulosclerosis, tubulointerstitial fibrosis, extracellular matrix (ECM) accumulation.

Adabiyotlar

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