Biomeditsina va amaliyot jurnali, 2022 №1

Maqola mavzusi



ABDASHIMOV Zafar Bakhtiyarovich


Tashkent State Dental Institute


The most clinically significant polymorphic markers of the CYP2C9 gene are the amino acid substitutions CYP2C9*2 (substitution in the 144 position of the polypeptide chain, leading to the substitution of the amino acid arginine for cysteine; 144Arg) and CYP2C9*3 (substitution in the 359 position of the polypeptide chain, leading to the substitution of the amino acid isoleucine for leucine; 359Leu). The genetic polymorphism of CYP 2C19 has pronounced interindividual differences. The significance of genetic polymorphism is determined when the occurrence of variant alleles is more than 1% in the population.

Kalit so'zlar

polymorphic marker of the CYP 2C9 gene, polymorphic marker of the CYP 2C19 gene, genetics, volunteers, Uzbek nationality.


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